Background: African American women more often present with more aggressive types of
breast cancer than Caucasian women, but little is known whether genetic polymorphisms …

The cytochrome p450 family 19 gene (CYP19A1) encodes for aromatase, which catalyzes
the final step in estrogen biosynthesis and conversion of androgens to estrogens. Genetic …

Objectives: Recent studies show that an Mspl polymorphism in the 3'-noncoding region of
the CYP1A1 gene is associated with breast cancer in African-American women but not in …

Common polymorphisms in genes that affect estrogen levels may be associated with breast
cancer risk. We investigated the associations between breast cancer and sequence variants …

Although many studies have examined associations between single nucleotide
polymorphisms (SNPs) in the CYP1A1, CYP1A2 and CYP1B1 genes and breast cancer risk …

Introduction Previous epidemiologic studies suggest that women with variant cytochrome
P4501A1 (CYP1A1) genotypes who smoke cigarettes are at increased risk for breast cancer …

CYP1B1 is a key enzyme involved in estrogen metabolism and may play an important role in
the development and progression of breast cancer. In a population-based case-control …

Abstract Cytochrome P-450 (CYP) 1A1 plays a key role in phase I metabolism of polycyclic
aromatic hydrocarbons and in estrogen metabolism. It is expressed predominantly in …

Reasons for the recent trend of increasing breast cancer incidence among Chinese and
other Asian women are not well understood. Endogenous estrogen levels are strongly …

Estrogens play a central role in the etiology of breast cancer. The CYP19A1 gene encodes
aromatase, a key enzyme in the biosynthesis of estrogens. Several single nucleotide …