FGF21 mediating sex dependent response to dietary macronutrients
KA Soto Sauza, KK Ryan - The Journal of Clinical Endocrinology …, 2024 - academic.oup.com
Sex is key variable influencing body composition and substrate utilization. At rest, females
maintain greater adiposity than males and resist the mobilization of fat. Males maintain …
maintain greater adiposity than males and resist the mobilization of fat. Males maintain …
[HTML][HTML] The nuanced metabolic functions of endogenous FGF21 depend on the nature of the stimulus, tissue source, and experimental model
RA Spann, CD Morrison, LJ den Hartigh - Frontiers in endocrinology, 2022 - frontiersin.org
Fibroblast growth factor 21 (FGF21) is a hormone that is involved in the regulation of lipid,
glucose, and energy metabolism. Pharmacological FGF21 administration promotes weight …
glucose, and energy metabolism. Pharmacological FGF21 administration promotes weight …
A new frontier in FGF21 biology
MJ Potthoff - Nature Reviews Endocrinology, 2017 - nature.com
In 2016, four studies were published that provided crucial new information on the endocrine
actions of the hormone fibroblast growth factor 21 (FGF21). These studies provide a …
actions of the hormone fibroblast growth factor 21 (FGF21). These studies provide a …
Mechanism for the effects of FGF21
C Greenhill - Nature Reviews Endocrinology, 2020 - nature.com
Fibroblast growth factor 21 (FGF21) has a wellestablished role in modulating macronutrient
uptake; it is pro duced by the liver in response to high-carbohydrate ingestion to signal to the …
uptake; it is pro duced by the liver in response to high-carbohydrate ingestion to signal to the …
Parsing the potential neuroendocrine actions of FGF21 in primates
MP Gillum - Endocrinology, 2018 - academic.oup.com
Abstract Fibroblast growth factor (FGF) 21, a unique, largely liver-derived endocrine member
of the FGF superfamily, is often thought of as a fasting factor owing to its induction in rodents …
of the FGF superfamily, is often thought of as a fasting factor owing to its induction in rodents …
[HTML][HTML] FGF21: a novel regulator of glucose and lipid metabolism and whole-body energy balance
E Szczepańska… - Hormone and Metabolic …, 2022 - thieme-connect.com
Fibroblast growth factor (FGF) 21 is a recently recognized metabolic regulator that evokes
interest due to its beneficial action of maintaining whole-body energy balance and protecting …
interest due to its beneficial action of maintaining whole-body energy balance and protecting …
FGF21 as an endocrine regulator in lipid metabolism: from molecular evolution to physiology and pathophysiology
Y Murata, M Konishi, N Itoh - Journal of nutrition and …, 2011 - Wiley Online Library
The FGF family comprises twenty‐two structurally related proteins with functions in
development and metabolism. The Fgf21 gene was generated early in vertebrate evolution …
development and metabolism. The Fgf21 gene was generated early in vertebrate evolution …
Liver fat but not other adiposity measures influence circulating FGF21 levels in healthy young adult twins
H Tyynismaa, T Raivio, A Hakkarainen… - The Journal of …, 2011 - academic.oup.com
abstract Context: Emerging as an important metabolic regulator, fibroblast growth factor 21
(FGF21) has gained considerable interest in diabetes and obesity research. The circulating …
(FGF21) has gained considerable interest in diabetes and obesity research. The circulating …
[PDF][PDF] FGF21 regulates metabolism through adipose-dependent and-independent mechanisms
FGF21 is an endocrine hormone that regulates energy homeostasis and insulin sensitivity.
The mechanism of FGF21 action and the tissues responsible for these effects have been …
The mechanism of FGF21 action and the tissues responsible for these effects have been …
Nutritional regulation of hepatic FGF21 by dietary restriction of methionine
FGF21 is a potent metabolic regulator of energy balance, body composition, lipid
metabolism, and glucose homeostasis. Initial studies reported that it was increased by …
metabolism, and glucose homeostasis. Initial studies reported that it was increased by …