The hallmark of sickle cell disease is the polymerization of sickle haemoglobin due to a point
mutation in the β‐globin gene (HBB). Under low oxygen saturation, sickle haemoglobin …

Sickle cell disease is characterized by hemolytic anemia, vasoocclusion and early mortality.
Polymerization of hemoglobin S followed by red blood cell sickling and subsequent vascular …

Background: Sickle cell disease (SCD) is caused by polymerization of Hemoglobin S,
resulting in red blood cell (RBC) sickling, RBC destruction, vaso-occlusive episodes and …

A major driver of the pathophysiology of sickle cell disease (SCD) is polymerization of
deoxygenated haemoglobin S (HbS), which leads to sickling and destruction of red blood …

Sickle cell anemia is a genetic disorder characterized by mutant hemoglobin (Hb)
polymerization and resultant cell deformation (sickling) under conditions of reduced oxygen …

In an attempt to find new types of anti‐sickling agents that specifically bind to intracellular
sickle haemoglobin (HbS) without inhibition by plasma and tissue proteins or other …

Polymerization of HbS and cell sickling are the prime pathophysiological events in sickle cell
disease (SCD). Over the last 30 years, a substantial understanding at the molecular level …

Compounds that bind to sickle hemoglobin (Hb S) producing an allosteric shift to the high‐
affinity Hb S that does not polymerize are being developed to treat sickle cell anemia (SCA) …

Sickle cell anemia occurs in individuals who are homozygous for a single nucleotide
substitution in codon 6 of the beta-globin gene. This single mutation leads to the formation of …

Candidate drugs to counter intracellular polymerization of deoxygenated sickle hemoglobin
(Hb S) continue to represent a promising approach to mitigating the primary cause of the …