Diastolic blood pressure and intensive blood pressure control on cognitive outcomes: insights from the SPRINT MIND trial

C Jiang, S Li, Y Wang, Y Lai, Y Bai, M Zhao, L He… - …, 2023 - Am Heart Assoc
Background: The potential benefits or harms of intensive systolic blood pressure (BP) control
on cognitive function and cerebral blood flow in individuals with low diastolic blood pressure …

[HTML][HTML] Effects of intensive vs. standard blood pressure control on cognitive function: Post-hoc analysis of the STEP randomized controlled trial

J Fan, J Bai, W Liu, J Cai - Frontiers in Neurology, 2023 - frontiersin.org
Background The STEP (Strategy of Blood Pressure Intervention in the older Hypertensive
Patients) trial showed that intensive systolic blood pressure (SBP) control resulted in a lower …

Effects of intensive versus standard blood pressure control on domain-specific cognitive function: a substudy of the SPRINT randomised controlled trial

SR Rapp, SA Gaussoin, BC Sachs, G Chelune… - The Lancet …, 2020 - thelancet.com
Summary Background Results from the Systolic Blood Pressure Intervention Trial (SPRINT)
showed that intensive control of systolic blood pressure significantly reduced the occurrence …

[HTML][HTML] Intensive blood pressure lowering prevents mild cognitive impairment and possible dementia and slows development of white matter lesions in brain: the …

SE Kjeldsen, K Narkiewicz, M Burnier, S Oparil - Blood pressure, 2018 - Taylor & Francis
The Systolic Blood Pressure Intervention Trial (SPRINT) tested the hypothesis that intensive
blood pressure (BP) control to a systolic BP target< 120mm Hg would reduce cardiovascular …

Systolic blood pressure time in target range and cognitive outcomes: insights from the SPRINT MIND trial

S Li, C Jiang, Y Wang, Y Lai, M Zhao, Q Li, Y Bai… - …, 2023 - Am Heart Assoc
BACKGROUND: The prognostic value of systolic blood pressure (SBP) time in target range
(TTR) on cognitive outcomes among adults with hypertension remains unclear. METHODS …

Evaluation of intensive vs standard blood pressure reduction and association with cognitive decline and dementia: a systematic review and meta-analysis

C Dallaire-Théroux, MH Quesnel-Olivo… - JAMA Network …, 2021 - jamanetwork.com
Importance Optimal blood pressure (BP) targets for the prevention of cognitive impairment
remain uncertain. Objective To explore the association of intensive (ie, lower than usual) BP …

Identifying patients for intensive blood pressure treatment based on cognitive benefit: a secondary analysis of the SPRINT randomized clinical trial

L Ghazi, J Shen, J Ying, CG Derington… - JAMA Network …, 2023 - jamanetwork.com
Importance Intensive vs standard treatment to lower systolic blood pressure (SBP) reduces
risk of mild cognitive impairment (MCI) or dementia; however, the magnitude of cognitive …

Association of intensive vs standard blood pressure control with cerebral blood flow: secondary analysis of the SPRINT MIND randomized clinical trial

S Dolui, JA Detre, SA Gaussoin, JS Herrick… - JAMA …, 2022 - jamanetwork.com
Importance Antihypertensive treatments benefit cerebrovascular health and cognitive
function in patients with hypertension, but it is uncertain whether an intensive blood pressure …

Prevention of cognitive impairment with intensive systolic blood pressure control

K Yaffe - Jama, 2019 - jamanetwork.com
The prevalence of Alzheimer disease (AD) and related dementia is expected to triple over
the next 30 years in the United States and worldwide. 1 Alzheimer disease drug …

Increased blood pressure variability and the risk of probable dementia or mild cognitive impairment: a post hoc analysis of the SPRINT MIND trial

A de Havenon, M Anadani, S Prabhakaran… - Journal of the …, 2021 - Am Heart Assoc
Background Increased systolic blood pressure variability (BPV) is associated with stroke,
cardiovascular disease, and dementia and mild cognitive impairment. However, prior …