Introduction Controlled release (CR) dosage forms comprise a wide range of technologies,
which modify the drug pharmacokinetic (PK) profile by avoiding the immediate release (IR) …

Controlled release of drugs is one of the most significant advances in pharmacy. Due to the
proposition of new routes for drug administration, today it is considered as a part of 'drug …

Controlled release dosage forms provide additional temporal and spatial control of drug
release not achievable by conventional or immediate release dosage forms. As a result …

Over the past 30 years, as the expense and complications involved in marketing new drug
entities have increased, with concomitant recognition of the therapeutic advantages of …

Now days as the expense and complications involved in marketing new drug entities are
increased, with concomitant recognition of the therapeutic advantages of controlled drug …

In light of the FDA's recent guidances regarding oral modified release dosage forms, there is
an increased awareness of the potential relevance of dissolution tests (1, 2). What was at …

This chapter reviews oral controlled-release (CR) systems, with a focus on dosage-form
characteristics and gastrointestinal (GI) physiology. Since an understanding of the basic …

In the Pharmaceutical Industry, as product devel-opment continues to multiply at
increasingly faster rates, dissolution method development must be able to keep pace with …

Proper medication dissolution must be ensured when developing or manufacturing a new
solid dosage form. Quantitative analyses performed in dissolution or release tests become …

Controlled-release drug delivery design involves the application of physical and polymer
chemistry to dosage-form design to produce a well-characterized and reproducible dosage …