[图书][B] Beyond Enhancer-Promoter Contact: Leveraging Deep Learning to Connect Super-Resolution DNA Traces to Transcription
AR Rajpurkar - 2021 - search.proquest.com
Chromatin architecture plays an important role in gene regulation. Recent advances in
super-resolution microscopy have made it possible to measure chromatin 3D structure and …
super-resolution microscopy have made it possible to measure chromatin 3D structure and …
[HTML][HTML] Deep learning connects DNA traces to transcription to reveal predictive features beyond enhancer–promoter contact
AR Rajpurkar, LJ Mateo, SE Murphy… - Nature …, 2021 - nature.com
Chromatin architecture plays an important role in gene regulation. Recent advances in
super-resolution microscopy have made it possible to measure chromatin 3D structure and …
super-resolution microscopy have made it possible to measure chromatin 3D structure and …
Coupling chromatin structure and dynamics by live super-resolution imaging
Chromatin conformation regulates gene expression and thus, constant remodeling of
chromatin structure is essential to guarantee proper cell function. To gain insight into the …
chromatin structure is essential to guarantee proper cell function. To gain insight into the …
Super-resolution imaging reveals distinct chromatin folding for different epigenetic states
Metazoan genomes are spatially organized at multiple scales, from packaging of DNA
around individual nucleosomes to segregation of whole chromosomes into distinct …
around individual nucleosomes to segregation of whole chromosomes into distinct …
[HTML][HTML] Tracking live-cell single-molecule dynamics enables measurements of heterochromatinassociated protein-protein interactions
Visualizing and measuring molecular-scale interactions in living cells represents a major
challenge, but recent advances in microscopy are bringing us closer to achieving this goal …
challenge, but recent advances in microscopy are bringing us closer to achieving this goal …
Super-resolution imaging of chromatin and functional nuclear architecture
M Ball - 2023 - repository.cam.ac.uk
The regulation of transcription is well understood to be linked to the three-dimensional
organisation of the genome within the nucleus, however, the mechanisms through which the …
organisation of the genome within the nucleus, however, the mechanisms through which the …
[图书][B] Applying Super-resolution Microscopy to Investigate the Regulatory Structure of the Genome
LJ Mateo - 2021 - search.proquest.com
Abstract The three-dimensional (3D) organization of the genome is important for cellular
function, such as gene expression and differentiation throughout development. Both the …
function, such as gene expression and differentiation throughout development. Both the …
Super-resolution imaging reveals 3D structure and organizing mechanism of accessible chromatin
Access to cis-regulatory elements packaged in chromatin is essential for directing gene
expression and cell viability. Here, we report a super-resolution imaging strategy, 3D ATAC …
expression and cell viability. Here, we report a super-resolution imaging strategy, 3D ATAC …
[HTML][HTML] Light-sheet Bayesian microscopy enables deep-cell super-resolution imaging of heterochromatin in live human embryonic stem cells
Background Heterochromatin in the nucleus of human embryonic cells plays an important
role in the epigenetic regulation of gene expression. The architecture of heterochromatin …
role in the epigenetic regulation of gene expression. The architecture of heterochromatin …
[HTML][HTML] Single-cell absolute contact probability detection reveals chromosomes are organized by multiple low-frequency yet specific interactions
DI Cattoni, AM Cardozo Gizzi, M Georgieva… - Nature …, 2017 - nature.com
At the kilo-to megabase pair scales, eukaryotic genomes are partitioned into self-interacting
modules or topologically associated domains (TADs) that associate to form nuclear …
modules or topologically associated domains (TADs) that associate to form nuclear …