Estrogens are essential for female reproduction and overall well-being, and estrogens in the
circulation are largely synthesized in ovarian granulosa cells. Using primary cultures of …

Estrogens are essential for female reproduction and overall well-being, and estrogens in the
circulation are largely synthesized in ovarian granulosa cells. Using primary cultures of …

This study was to explore estrogen receptor (ER) involvement in FSH and TGFβ1-stimulated
steroidogenesis in rat ovarian granulosa cells. We first determined the specific involvement …

In vitro and in vivo studies implicate that follicle‐stimulating hormone (FSH) and transforming
growth factor β1 (TGFβ1) play crucial physiological roles in regulating ovarian granulosa cell …

The TGF-β superfamily members are indicated to play key roles in ovarian follicular
development, such as granulosa cell proliferation, estrogens, and progesterone production …

Steroid biosynthesis in ovary is enhanced by the orphan nuclear receptor, steroidogenic
factor-1 (SF-1); however, we reported that liver receptor homolog-1 (LRH-1), a closely …

Excessive exposure to estradiol represents the main risk factor for endometrial cancer. The
abnormally high estradiol levels in the endometrium of women with endometrial cancer are …

Our goal is to define the cellular and molecular mechanisms for tissue-and cell-specific,
developmental and hormonal regulation of the human CYP19 (aromatase P450/P450arom) …

Transforming growth factor (TGF) β1 facilitates FSH-induced differentiation of rat ovarian
granulosa cells. The signaling crosstalk between follicle stimulating hormone (FSH) and …

Ovaries represent one of the primary steroidogenic organs, producing estrogen and
progesterone under the regulation of gonadotropins during the estrous cycle. Gonadotropins …