Bifunctional gallium-68 chelators: Past, present, and future

P Spang, C Herrmann, F Roesch - Seminars in nuclear medicine, 2016 - Elsevier
This article reviews the development of bifunctional chelates for synthesising 68 Ga
radiopharmaceuticals. It structures the chelates into groups of macrocycles …

Recent advances in chelator design and labelling methodology for 68Ga radiopharmaceuticals

BP Burke, GS Clemente… - Journal of Labelled …, 2014 - Wiley Online Library
Gallium‐68 has the potential to become the technetium‐99m of positron emission
tomography with ideal decay characteristics and a long‐lived parent isotope for generator …

[HTML][HTML] Modern developments in bifunctional chelator design for gallium radiopharmaceuticals

PRWJ Davey, BM Paterson - Molecules, 2022 - mdpi.com
The positron-emitting radionuclide gallium-68 has become increasingly utilised in both
preclinical and clinical settings with positron emission tomography (PET). The synthesis of …

Clinical applications of Gallium-68

SR Banerjee, MG Pomper - Applied Radiation and Isotopes, 2013 - Elsevier
Gallium-68 is a positron-emitting radioisotope that is produced from a 68Ge/68Ga generator.
As such it is conveniently used, decoupling radiopharmacies from the need for a cyclotron …

68Ge/68Ga Generators: Past, Present, and Future

F Rösch - Theranostics, Gallium-68, and Other Radionuclides: A …, 2012 - Springer
Abstract In 1964, first 68 Ge/68 Ga radionuclide generators were described. Although the
generator design was by far not adequate to our today's level of chemical …

[HTML][HTML] Comparison of macrocyclic and acyclic chelators for gallium-68 radiolabelling

MI Tsionou, CE Knapp, CA Foley, CR Munteanu… - RSC …, 2017 - pubs.rsc.org
Gallium-68 (68Ga) is a positron-emitting isotope used for clinical PET imaging of peptide
receptor expression. 68Ga radiopharmaceuticals used in molecular PET imaging consist of …

[HTML][HTML] 68Ga-DOTA and analogs: Current status and future perspectives

K Kilian - Reports of Practical Oncology & Radiotherapy, 2014 - Elsevier
The construction of the 68 Ge/68 Ga generator has increased application of
radiopharmaceuticals labeled with this isotope in medicine. 68 Ga-PET is widely employed …

Gallium-68 in medical imaging

L Martiniova, LD Palatis, E Etchebehere… - Current …, 2016 - ingentaconnect.com
Over the past several years, Positron Emission Tomography (PET) imaging agents labeled
with 68Gallium (68Ga) have undergone a significant increase in clinical utilization. 68Ga is …

Gallium-68: a new trend in PET radiopharmacy

IM Prata - Current radiopharmaceuticals, 2012 - ingentaconnect.com
The most common PET radioisotopes, both in the literature and in clinical practice, are the
cyclotron produced 11C and 18F, giving rise to tracers with minimal chemical changes with …

Rapid and automated production of [68Ga] gallium chloride and [68Ga] Ga-DOTA-TATE on a medical cyclotron

W Tieu, CA Hollis, KKW Kuan, P Takhar… - Nuclear Medicine and …, 2019 - Elsevier
Abstract Introduction The demand for Gallium-68 (68 Ga) for labelling PET
radiopharmaceuticals has increased over the past few years. 68 Ga is obtained through the …