High-throughput methods for slide-free three-dimensional (3D) pathological analyses of
whole biopsies and surgical specimens offer the promise of modernizing traditional …

Imaging is vital for the assessment of physiologic and phenotypic details. In the past,
biomedical imaging was heavily reliant on analog, low-throughput methods, which would …

Three-dimensional (3D) reconstruction and examination of tissue at microscopic resolution
have significant potential to enhance the study of both normal and disease processes …

For the 1.7 million patients per year in the US who receive a new cancer diagnosis,
treatment decisions are largely based on histopathological specimen examinations …

The examination of hematoxylin and eosin (H&E)-stained tissues on glass slides by
conventional light microscopy is the foundation for histopathological diagnosis. However …

Understanding the structure–function relationship of cells and organelles in their natural
context requires multidimensional imaging. As techniques for multimodal 3-D imaging have …

Histology permits the observation of otherwise invisible structures of the internal topography
of a specimen. Although it enables the investigation of tissues at a cellular level, it is invasive …

Historically, micro-computed tomography (μCT) has been considered unsuitable for
histologic analysis of unstained formalin-fixed, paraffin-embedded soft tissue biopsy …

Organ homeostasis, cellular differentiation, signal relay, and in situ function all depend on
the spatial organization of cells in complex tissues. For this reason, comprehensive, high …

Spatial molecular profiling of complex tissues is essential to investigate cellular function in
physiological and pathological states. However, methods for molecular analysis of large …