A growing number of epidemiological and experimental studies has established that
circadian disruption is strongly associated with psychiatric disorders, including major …

Conventional antidepressants require 2–8 weeks for a full clinical response. In contrast, two
rapidly acting antidepressant interventions, low-dose ketamine and sleep deprivation (SD) …

In humans almost all physiological and behavioural functions occur on a rhythmic basis.
Therefore the possibility that delays, advances or desynchronizations of circadian rhythms …

Depression, particularly unipolar depression, has often been linked to circadian (ie
approximately 24-h) rhythm abnormalities. The observation that many diverse rhythms are …

Affective disorders such as major depression, bipolar disorder, and seasonal affective
disorder are associated with major disruptions in circadian rhythms. Indeed, altered …

The clinical observations of diurnal variation of mood and early morning awakening in
depression have been incorporated into established diagnostic systems, as has the …

Background A long-standing challenge in the treatment of depression is the development of
a rapidly acting antidepressant. Conventional antidepressants typically require 2–8 weeks …

Objective The aim of this article is to review progress in understanding the mechanisms that
underlie circadian and sleep rhythms, and their role in the pathogenesis and treatment of …

Circadian rhythms are near 24-h cycles in a number of physiological and behavioural
parameters and the underpinning circadian timing systems is one of the key homeostatic …

Mood disorders are serious diseases that affect a large portion of the population. There have
been many hypotheses put forth over the years to explain the development of major …