Selective functionalization of a single sp3 C–F bond of the CF3 group represents an
appealing way to generate the pharmaceutically privileged difluoromethylene moiety …

Introduction of a difluoromethyl (CF2H) unit into organic molecules is of specific interest in
medicinal chemistry and chemical biology, as compounds with a CF2H moiety can act as an …

The triple ipso-defluoroetherification of (trifluoromethyl) alkenes with fluoroalkylated alcohols
by C (sp3)–F bond cleavage is reported, delivering various fluoroalkylated orthoesters in …

Difunctionalizing trifluoromethylation of carbon-carbon multiple bonds has recently
developed into a robust tool for preparation of complex CF 3-functionalized molecules …

Fluorine‐containing moieties are widely used in the pharmaceutical, agrochemical, and
material fields. Thus, these structures are of immense interest in the fields of organic …

Fluorinated functional groups, including trifluoromethyl group, play important roles in the
development of drugs, agrochemicals, and organic functional materials. Therefore, the …

Abstract The 2, 2‐difluoroethyl group is an important lipophilic hydrogen bond donor in
medicinal chemistry, but its incorporation into small molecules is often challenging. Herein …

As we know, the incorporation of a trifluoromethyl group into organic molecules may
significantly alter their physical and biological properties due to the high electronegativity …

A facile, efficient, single-step protocol for the synthesis of difluoromethyl enol ether
derivatives by O-difluoromethylation of 1, 3-diones via in situ generation of difluorocarbene …

The selective activation of inert C–F bonds is one of the most challenging topics in modern
organic chemistry. Trifluoromethylketones represent a class of versatile building blocks that …