Our concept of a stable genome is evolving to one in which genomes are plastic and
responsive to environmental changes. Growing evidence shows that a variety of …

Genomic instability underlies many cancers and generates genetic variation that drives
cancer initiation, progression, and therapy resistance. In contrast with classical assumptions …

Evolutionary theory assumed that mutations occur constantly, gradually, and randomly over
time. This formulation from the “modern synthesis” of the 1930s was embraced decades …

“Adaptive mutation” denotes a collection of processes in which cells respond to growth-
limiting environments by producing compensatory mutants that grow well, apparently …

Increased mutation rates under stress allow bacterial populations to adapt rapidly to
stressors, including antibiotics. Here we evaluate existing models for the evolution of stress …

Mutations drive evolution and were assumed to occur by chance: constantly, gradually,
roughly uniformly in genomes, and without regard to environmental inputs, but this view is …

Under stressful conditions mechanisms that increase genetic variation can bestow a
selective advantage. Bacteria have several stress responses that provide ways in which …

Comparative biochemistry demonstrates that the metabolites, complex biochemical
networks, enzymes and regulatory mechanisms essential to all living cells are conserved in …

Bacteria spend their lives buffeted by changing environmental conditions. To adapt to and
survive these stresses, bacteria have global response systems that result in sweeping …

Conditions of chronic stress are associated with genetic instability in many organisms, but
the roles of stress responses in mutagenesis have so far been elucidated only in bacteria …