Microsatellite instability (MI+) is associated with defects in mismatch repair, resulting in a
'mutator'phenotype and the development and progression of cancer. MI+ has been …

Sporadic cancers and familial breast cancers are characterized by an increase in genetic
instability. Little is known about whether mismatch repair defects accompany this genetic …

Microsatellite instability is a form of genetic damage that may be due to defective mismatch
repair genes and may be a marker of processes leading to malignancy. We have analysed a …

Allelic imbalance or loss of heterozygosity (LOH) studies have been used extensively to
identify regions on chromosomes that may contain putative tumour suppressor genes. We …

Microsatellite instability (MSI) is a form of genetic instability that results from defects in DNA
mismatch repair. MSI is reported to be rare in unselected breast cancers, however it is a …

The molecular pathogenesis of various categories of breast cancer (BC) has been well
described, but surprisingly few reports have appeared on analysis of somatic mutations in …

Recent studies have suggested that breast cancer is part of the tumor spectrum in Lynch
syndrome (LS). However, the frequency and significance of DNA mismatch repair (MMR) …

Microsatellite instability (MSI) has been described in colorectal and other cancers. The
purpose of this study was to determine the presence of MSI in breast cancer and to correlate …

Microsatellite instability was analysed in 93 primary breast tumours at 13 chromosomal loci
frequently altered in breast cancer. RER (replication errors) were observed at a low (5%) …

We have studied the incidence of microsatellite instability at three trinucleotide repeats and
seven dinucleotide repeats from five chromosomal regions, in a group of 30 …