Integrase is the retroviral protein responsible for integrating reverse transcripts into cellular
genomes. Co-packaged with viral RNA and reverse transcriptase into capsid-encased viral …

A large number of human immunodeficiency virus 1 (HIV-1) integrase (IN) alterations,
referred to as class II substitutions, exhibit pleiotropic effects during virus replication …

The viral integrase (IN) protein is the only viral protein known to be required for integration of
the human immunodeficiency virus type 1 (HIV-1) genome into the host cell DNA, a step in …

During infection, human immunodeficiency virus type 1 integrase engages a number of
molecules and mechanisms, both of viral and cellular origin. In one of such instances …

Previous biochemical and genetic evidence indicated that the functional form of retroviral
integrase protein (IN) is a multimer. A direct demonstration of IN oligomerization during the …

While an essential role of HIV-1 integrase (IN) for integration of viral cDNA into human
chromosome is established, studies with IN mutants and allosteric IN inhibitors (ALLINIs) …

The HIV-1 integrase enzyme (IN) plays a critical role in the viral life cycle by integrating the
reverse-transcribed viral DNA into the host chromosome. This function of IN has been well …

Recent evidence indicates that inhibition of HIV-1 integrase (IN) binding to the viral RNA
genome by allosteric integrase inhibitors (ALLINIs) or through mutations within IN yields …

Retroviral integrase catalyzes the essential step of integrating a double-stranded DNA copy
of the viral genome into a host cell chromosome. Mutational studies have revealed that …

ABSTRACT HIV-1 integrase (IN) has a noncatalytic function in virion maturation through its
binding to the viral RNA genome (gRNA). Class II IN substitutions inhibit IN-gRNA binding …