Background Neutrophilic asthma is associated with disease severity and corticosteroid
insensitivity. Novel therapies are required to manage this life-threatening asthma phenotype …

Studies examining the role of PD‐1 family members in allergic asthma have yielded
conflicting results. Using a mouse model of allergic asthma, we demonstrate that blockade of …

The prolyl hydroxylase domain-containing enzymes (PHDs) are important metabolic sensors
of the cell and its environment, which might be employed to alert cells of the immune system …

Prostaglandins (PGs) can enhance or suppress inflammation by acting on different receptors
expressed by hematopoietic and nonhematopoietic cells. Prostaglandin D2 binds to the D …

Programmed death one homolog (PD-1H) is a cell surface molecule of the B7/CD28
immune modulatory gene family. Although PD-1H has been shown to function as a …

Allergic asthma is a leading chronic disease associated with airway hyperreactivity (AHR).
Type-2 innate lymphoid cells (ILC2s) are a potent source of T-helper 2 (Th2) cytokines that …

BACKGROUND: Asthma is defined as a chronic inflammatory disease of the airways;
however, the underlying physiologic and immunologic processes are not fully understood …

Dendritic cells (DCs) are critical in asthma and many other immune diseases. We previously
demonstrated a role for PARP‐1 in asthma. Evidence on PARP‐1 playing a role in Th2 …

Background Although acute exacerbations, mostly triggered by viruses, account for the
majority of hospitalizations in asthmatic patients, there is still very little known about the …

Studies examining the role of programmed death 1 (PD-1) ligand 2 (PD-L2)/PD-1 in asthma
have yielded conflicting results. To clarify its role, we examined the PD-L2 expression in …