The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently
overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF …

Introduction: The insulin-like growth factors (IGFs) are a family of secreted peptide hormones
with important roles in different cellular and organism functions. The biological activities of …

Research conducted over the past two decades has shown the importance of the type 1
insulin-like growth factor receptor (IGF1R) in tumorigenesis, metastasis, and resistance to …

The type 1 insulin-like growth factor receptor (IGF1R) is overexpressed by many tumors, and
mediates growth, motility and protection from apoptosis. Inhibition of IGF1R expression or …

The insulin and insulin-like growth factor (IGF) system plays an important role in regulating
normal cell proliferation and survival. However, the IGF system is also implicated in many …

The insulin-like growth factor (IGF) signaling system plays a crucial role in human cancer
and the IGF-1 receptor (IGF-1R) is an attractive drug target against which a variety of novel …

The importance of insulin-like growth factor 1 receptor (IGF-1R) signalling in malignant
behaviour of tumour cells is well established. Currently, development of drugs targeting the …

Signaling through the insulin-like growth factor receptor (IGF-1R) is required for neoplastic
transformation by a number of oncogenes, and preclinical validation studies have suggested …

Insulin-like growth factor 1 (IGF1) is a polypeptide hormone that has a high degree of
structural similarity to human proinsulin. Owing to its ubiquitous nature and its role in …

During the last decades, changes in the insulin-like growth factor (IGF) signaling have been
related to the pathogenesis of cancer. Therefore, IGFs became highly attractive therapeutic …