Proanthocyanidin and sodium butyrate synergistically modulate rat colon carcinogenesis by scavenging free radicals and regulating the COX-2 and APC pathways

EI Salim, SMS El-Halawany, HA Hassan… - The Journal of Basic and …, 2023 - Springer
Background The purpose of this study was to explore the effects of sodium butyrate (NaB),
grape seed proanthocyanidin extract (GSPE), or their combination against …

Chemoprevention of colorectal cancer by grape seed proanthocyanidin is accompanied by a decrease in proliferation and increase in apoptosis

H Nomoto, M Iigo, H Hamada, S Kojima… - Nutrition and …, 2004 - Taylor & Francis
Effects of proanthocyanidin (PA), procyanidin B-2 (B-2), and epigallocatechin gallate
(EGCG) on azoxymethane (AOM)-induced colonic preneoplastic aberrant crypt foci (ACF) …

Apigenin and naringenin suppress colon carcinogenesis through the aberrant crypt stage in azoxymethane-treated rats

T Leonardi, J Vanamala, SS Taddeo… - Experimental …, 2010 - journals.sagepub.com
Epidemiological evidence suggests that a diet abundant in fruits and vegetables may protect
against colon cancer. Bioactive compounds, including flavonoids and limonoids, have been …

Apple proanthocyanidins do not reduce the induction of preneoplastic lesions in the colon of rats associated with human microbiota

EF Lhoste, A Bruneau, M Bensaada… - Journal of agricultural …, 2010 - ACS Publications
Since the gut microbiota metabolizes various dietary constituents unabsorbed by the small
intestine and modulates colon function, it plays an essential role in colon carcinogenesis …

[PDF][PDF] Dietary cardamom inhibits the formation of azoxymethane-induced aberrant crypt foci in mice and reduces COX-2 and iNOS expression in the colon

A Sengupta, S Ghosh, S Bhattacharjee - Asian Pac J Cancer Prev, 2005 - academia.edu
Recently, considerable attention has been focused on identifying naturally occurring
chemopreventive compounds capable of inhibiting, retarding, or reversing the multi-step …

DNA damage and aberrant crypt foci as putative biomarkers to evaluate the chemopreventive effect of annatto (Bixa orellana L.) in rat colon carcinogenesis

AR Agner, AP Bazo, LR Ribeiro… - Mutation Research/Genetic …, 2005 - Elsevier
Chemoprevention opens new perspectives in the prevention of cancer and other
degenerative diseases. Use of target-organ biological models at the histological and genetic …

Effect of grape seed proanthocyanidins on colon aberrant crypts and breast tumors in a rat dual-organ tumor model

KW Singletary, B Meline - Nutrition and cancer, 2001 - Taylor & Francis
Cancers of the colon and breast are two of the most prevalent cancers in developed
countries. The present experiments were conducted to determine the influence of several …

P0026 The chemopreventive potential of Curcuma purpurascens rhizome in reducing azoxymethane-induced aberrant crypt foci in rats

E Rouhollahi, SZ Moghadamtousi, MA Abdulla… - European Journal of …, 2015 - Elsevier
Background Curcuma purpurascens rhizome, a member of the Zingiberaceae family, is a
popular spice in Indonesia and is traditionally used for assorted remedies. Dichloromethane …

Pelargonidin, a dietary anthocyanidin in the prevention of colorectal cancer and its chemoprotective mechanisms

M Vaiyapuri, S Thimmarayan, M Dhupal… - Plant-derived Bioactives …, 2020 - Springer
Diseases of bowl wall mucosa stemming from sudden mutation lead to the development of
colorectal cancer (CRC) cells by the transformation of normal epithelial cells into neoplastic …

Dietary‐feeding of grape seed extract prevents azoxymethane‐induced colonic aberrant crypt foci formation in fischer 344 rats

B Velmurugan, RP Singh, R Agarwal… - Molecular …, 2010 - Wiley Online Library
Chemoprevention by dietary agents/supplements has emerged as a novel approach to
control various malignancies, including colorectal cancer (CRC). This study assessed …