Astaxanthin anticancer effects are mediated through multiple molecular mechanisms: A systematic review

I Faraone, C Sinisgalli, A Ostuni, MF Armentano… - Pharmacological …, 2020 - Elsevier
During the latest decades, the interest on the effectiveness of natural compounds and their
impact on human health constantly increased, especially on those demonstrating to be …

[HTML][HTML] Multiple mechanisms of anti-cancer effects exerted by astaxanthin

L Zhang, H Wang - Marine drugs, 2015 - mdpi.com
Astaxanthin (ATX) is a xanthophyll carotenoid which has been approved by the United
States Food and Drug Administration (USFDA) as food colorant in animal and fish feed. It is …

Therapeutic uses of natural astaxanthin: An evidence-based review focused on human clinical trials

A Donoso, J González-Durán, AA Muñoz… - Pharmacological …, 2021 - Elsevier
Astaxanthin is a natural C40 carotenoid with numerous reported biological functions, most of
them associated with its antioxidant and anti-inflammatory activity, standing out from other …

[HTML][HTML] Anti-oxidant and anti-inflammatory effects of astaxanthin on gastrointestinal diseases

J Lee, MH Kim, H Kim - International journal of molecular sciences, 2022 - mdpi.com
A moderate amount of reactive oxygen species (ROS) is produced under normal conditions,
where they play an important role in cell signaling and are involved in many aspects of the …

Zeaxanthin induces apoptosis via ROS-regulated MAPK and AKT signaling pathway in human gastric cancer cells

YN Sheng, YH Luo, SB Liu, WT Xu, Y Zhang… - OncoTargets and …, 2020 - Taylor & Francis
Background Zeaxanthin, a carotenoid commonly found in plants, has a variety of biological
functions including anti-cancer activity. Purpose This study aimed to investigate the potential …

Astaxanthin inhibits NF-κB and Wnt/β-catenin signaling pathways via inactivation of Erk/MAPK and PI3K/Akt to induce intrinsic apoptosis in a hamster model of oral …

K Kavitha, J Kowshik, TKK Kishore, AB Baba… - … et Biophysica Acta (BBA …, 2013 - Elsevier
Background The oncogenic transcription factors NF-κB and β-catenin, constitutively
activated by upstream serine/threonine kinases control several cellular processes implicated …

[HTML][HTML] Astaxanthin inhibits JAK/STAT-3 signaling to abrogate cell proliferation, invasion and angiogenesis in a hamster model of oral cancer

J Kowshik, AB Baba, H Giri, G Deepak Reddy, M Dixit… - PloS one, 2014 - journals.plos.org
Identifying agents that inhibit STAT-3, a cytosolic transcription factor involved in the
activation of various genes implicated in tumour progression is a promising strategy for …

Astaxanthin induces apoptosis and increases activity of antioxidant enzymes in LS-180 cells

M Hormozi, S Ghoreishi… - … cells, nanomedicine, and …, 2019 - Taylor & Francis
Astaxanthin, a Xanthophyll carotenoid, has strong antioxidant properties. Some studies have
shown the effectiveness of this compound on the prevention and treatment of cancer …

Astaxanthin: a review of its chemistry and applications

I Higuera-Ciapara, L Felix-Valenzuela… - Critical reviews in …, 2006 - Taylor & Francis
Astaxanthin is a carotenoid widely used in salmonid and crustacean aquaculture to provide
the pink color characteristic of that species. This application has been well documented for …

[HTML][HTML] Anti-inflammatory action of astaxanthin and its use in the treatment of various diseases

Z Kohandel, T Farkhondeh, M Aschner… - Biomedicine & …, 2022 - Elsevier
Astaxanthin (AST) is a red pigmented carotenoid with significant antioxidant, anti-
inflammatory, anti-proliferative, and anti-apoptotic properties. In this study, we summarize …