[HTML][HTML] Role of Immune Checkpoint Inhibitor Therapy in Advanced EGFR-Mutant Non-Small Cell Lung Cancer

N Wiest, U Majeed, K Seegobin, Y Zhao, Y Lou… - Frontiers in …, 2021 - frontiersin.org
Over the last decade, the treatment of advanced non-small cell lung cancer (NSCLC) has
undergone rapid changes with innovations in oncogene-directed therapy and immune …

Application of immune checkpoint inhibitors in EGFR-mutant non-small-cell lung cancer: from bed to bench

R Jin, J Zhao, L Xia, Q Li, W Li… - … advances in medical …, 2020 - journals.sagepub.com
Targeted therapies are efficient in the context of oncogenic driver mutations. Epidermal
growth factor receptor (EGFR)-mutant lung cancers represent a distinct subset of non-small …

[HTML][HTML] The efficacy of immune checkpoint inhibitors in advanced EGFR-Mutated non-small cell lung cancer after resistance to EGFR-TKIs: Real-World evidence from …

J Hu, D Huang, Y Wang, D Li, X Yang, Y Fu… - Frontiers in …, 2022 - frontiersin.org
Background The efficacy of immune checkpoint inhibitors (ICIs) in pretreated EGFR-mutated
non-small cell lung cancer (NSCLC) patients is controversial. We conducted this multicenter …

Efficacy and safety of immune checkpoint inhibitors in post-TKI NSCLC patients harboring EGFR mutations

S Sun, C Liu, C Duan, S Yu, Q Zhang, N Xu… - Journal of Cancer …, 2023 - Springer
Abstract Objective Immune checkpoint inhibitors (ICIs) have been validated in epidermal
growth factor receptor (EGFR) wild-type advanced non-small cell lung cancer (NSCLC) …

Immune checkpoint inhibitors in EGFR-mutant non-small cell lung cancer: a systematic review

I Attili, A Passaro, C Corvaja, PT Aliaga… - Cancer Treatment …, 2023 - Elsevier
Background Since their first introduction in clinical practice, immune checkpoint inhibitors
showed limited benefit in patients with NSCLC harboring EGFR mutations. With the rationale …

[HTML][HTML] Efficacy of immune checkpoint inhibitors in EGFR-Mutant NSCLC patients with EGFR-TKI resistance: A systematic review and meta-analysis

X Qian, X Guo, T Li, W Hu, L Zhang, C Wu… - Frontiers in …, 2022 - frontiersin.org
Background: Epidermal growth factor receptor (EGFR) mutations are common in patients
with non-small-cell lung cancer (NSCLC), particularly in Asian populations. Tyrosine kinase …

The efficacy and safety of immune checkpoint inhibitors for patients with EGFR‐mutated non‐small cell lung cancer who progressed on EGFR tyrosine‐kinase inhibitor …

Z Wang, F Zhou, S Xu, K Wang, H Ding - Cancer Medicine, 2023 - Wiley Online Library
Background Non‐small cell lung cancer (NSCLC) patients harboring epidermal growth
factor receptor (EGFR)‐mutated who progressed on EGFR tyrosine‐kinase inhibitor (EGFR …

Retrospective efficacy analysis of immune checkpoint inhibitors in patients with EGFR‐mutated non‐small cell lung cancer

T Yamada, S Hirai, Y Katayama, A Yoshimura… - Cancer …, 2019 - Wiley Online Library
Background Treatment with epidermal growth factor receptor (EGFR)‐tyrosine kinase
inhibitors (TKIs) leads to initial response in most patients with EGFR‐mutated non‐small cell …

The efficacy and possible mechanisms of immune checkpoint inhibitors in treating non‐small cell lung cancer patients with epidermal growth factor receptor mutation

L Ma, B Diao, Z Huang, B Wang, J Yu… - Cancer …, 2021 - Wiley Online Library
Over the past few years, immune checkpoint inhibitors (ICIs) have greatly improved the
survival for patients with non‐small cell lung cancer (NSCLC) without driver mutations …

[HTML][HTML] EGFR mutation subtype impacts efficacy of immune checkpoint inhibitors in non-small-cell lung cancer

M Früh, S Peters - Annals of Oncology, 2019 - annalsofoncology.org
Epidermal growth factor receptor (EGFR) mutations occur in 15% of lung adenocarcinomas
in the Caucasian population. A higher incidence is observed in never/light smokers and …