Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation,
engendering transcript diversity, and modifications in protein structure and functionality …

Alternative splicing (AS) is an important mechanism used to generate greater transcriptomic
and proteomic diversity from a finite genome. Nearly all human gene transcripts are …

Alternative splicing (AS) of protein-coding messenger RNAs is an essential regulatory
mechanism in eukaryotic gene expression that controls the proper function of proteins. It is …

High-throughput sequencing-based methods and their applications in the study of
transcriptomes have revolutionized our understanding of alternative splicing. Networks of …

Splicing of pre-RNA is a key step in regulating eukaryotic gene expression. Most human
genes undergo alternative splicing (AS), where the splice sites in a single gene can be …

Alternative splicing (AS) plays a critical role in enhancing proteome complexity in higher
eukaryotes. Almost all the multi intron-containing genes undergo AS in humans. Splicing …

Alternative splicing (AS) can generate distinct transcripts and subsequent isoforms that play
differential functions from the same pre-mRNA. Recently, increasing numbers of studies …

During tumor progression, hypoxia, nutrient deprivation or changes in the extracellular
environment (ie, induced by anti-cancer drugs) elicit adaptive responses in cancer cells …

Alternative splicing (AS) is one of the key processes involved in the regulation of gene
expression in eukaryotic cells. AS catalyzes the removal of intronic sequences and the …

Recent findings justify a renewed interest in alternative splicing (AS): the process is more a
rule than an exception as it affects the expression of 60% of human genes; it explains how a …