Implications on clinical scenario of gold nanoparticle radiosensitization in regards to photon energy, nanoparticle size, concentration and location

E Lechtman, N Chattopadhyay, Z Cai… - Physics in Medicine …, 2011 - iopscience.iop.org
Gold nanoparticle (AuNP) radiosensitization represents a novel approach to enhance the
effectiveness of ionizing radiation. Its efficiency varies widely with photon source energy and …

A Monte Carlo-based model of gold nanoparticle radiosensitization accounting for increased radiobiological effectiveness

E Lechtman, S Mashouf… - Physics in Medicine …, 2013 - iopscience.iop.org
Radiosensitization using gold nanoparticles (AuNPs) has been shown to vary widely with
cell line, irradiation energy, AuNP size, concentration and intracellular localization. We …

Gold nanoparticles as radiation sensitizers in cancer therapy

DB Chithrani, S Jelveh, F Jalali… - Radiation …, 2010 - meridian.allenpress.com
Among other nanoparticle systems, gold nanoparticles have been explored as
radiosensitizers. While most of the research in this area has focused on either gold …

Biological mechanisms of gold nanoparticle radiosensitization

S Rosa, C Connolly, G Schettino, KT Butterworth… - Cancer …, 2017 - Springer
There has been growing interest in the use of nanomaterials for a range of biomedical
applications over the last number of years. In particular, gold nanoparticles (GNPs) possess …

Radiosensitization by gold nanoparticles

B Jeremic, AR Aguerri, N Filipovic - Clinical and Translational Oncology, 2013 - Springer
Recent years brought increasing use of gold nano particles (GNP) as a model platform for
interaction of irradiation and GNPs aiming radiosensitization. Endocytosis seems to be one …

Radiosensitization by gold nanoparticles: Will they ever make it to the clinic?

L Cui, S Her, GR Borst, RG Bristow, DA Jaffray… - Radiotherapy and …, 2017 - Elsevier
The utilization of gold nanoparticles (AuNPs) as radiosensitizers has shown great promise in
pre-clinical research. In the current review, the physical, chemical, and biological pathways …

Estimation of tumour dose enhancement due to gold nanoparticles during typical radiation treatments: a preliminary Monte Carlo study

SH Cho - Physics in Medicine & Biology, 2005 - iopscience.iop.org
A recent mice study demonstrated that gold nanoparticles could be safely administered and
used to enhance the tumour dose during radiation therapy. The use of gold nanoparticles …

Dependence of gold nanoparticle radiosensitization on cell geometry

W Sung, SJ Ye, AL McNamara, SJ McMahon… - Nanoscale, 2017 - pubs.rsc.org
The radiosensitization effect of gold nanoparticles (GNPs) has been demonstrated both in
vitro and in vivo in radiation therapy. The purpose of this study was to systematically assess …

Roadmap to clinical use of gold nanoparticles for radiation sensitization

J Schuemann, R Berbeco, DB Chithrani, SH Cho… - International Journal of …, 2016 - Elsevier
The past decade has seen a dramatic increase in interest in the use of gold nanoparticles
(GNPs) as radiation sensitizers for radiation therapy. This interest was initially driven by their …

Cell type-dependent uptake, localization, and cytotoxicity of 1.9 nm gold nanoparticles

JA Coulter, S Jain, KT Butterworth… - International journal …, 2012 - Taylor & Francis
Background This follow-up study aims to determine the physical parameters which govern
the differential radiosensitization capacity of two tumor cell lines and one immortalized …