The chronic mild stress (CMS) model of depression has high validity but has in the past
been criticized for being difficult to replicate. However, a large number of recent publications …

This paper evaluates the validity, reliability and utility of the chronic mild stress (CMS) model
of depression. In the CMS model, rats or mice are exposed sequentially, over a period of …

Rationale The chronic mild stress (CMS) paradigm was first described almost 40 years ago
and has become a widely used model in the search for antidepressant drugs for major …

Now 30 years old, the chronic mild stress (CMS) model of depression has been used in>
1300 published studies, with a year-on-year increase rising to> 200 papers in 2015. Data …

Rationale Many studies support the validity of the chronic mild stress (CMS) model of
depression in rodents. However, most of them focus on analysis of reactivity to rewards …

The chronic mild stress (CMS) model of depression is considered by many to be the animal
model of depression that has the greatest validity and translational potential, but it has often …

The chronic mild (or unpredictable/variable) stress (CMS) model was developed as an
animal model of depression more than 20 years ago. The foundation of this model was that …

Chronic mild stress (CMS) has been reported to induce an anhedonic-like state in rats that
resembles some of the symptoms of endogenous depression in humans. In the present …

There have been few comparisons of strains and antidepressants in the unpredictable
chronic mild stress (UCMS) paradigm in mice. This study was undertaken to determine the …

The chronic stress model was developed on the basis of the stress–diathesis hypothesis of
depression. However, these behavioural responses associated with different stress …