Background Sepsis-associated destruction of the pulmonary microvascular endothelial
glycocalyx (EGCX) creates a vulnerable endothelial surface, contributing to the development …

Background Disruption of the endothelial glycocalyx contributes to acute lung injury in
experimental sepsis but has not been well studied in humans. To study glycocalyx …

Background Degradation of the endothelial glycocalyx is critical for sepsis-associated lung
injury and pulmonary vascular permeability. We investigated whether sulodexide, a …

Background The most recent diagnostic criteria for sepsis include organ failure.
Microvascular endothelial injury is believed to lead to the multiple organ failure seen in …

Background Scientific evidence indicates that endothelial glycocalyx (EG) shedding
contributes to the pathophysiological installation of acute respiratory distress syndrome …

The vascular endothelium is the interface between circulating blood and end organs and
thus has a critical role in preserving organ function. The endothelium is lined by a glycan …

Objective: To analyze the correlation between glycocalyx disruption measured via the serum
syndecan-1 level and organ dysfunctions assessed by the PELOD-2 score and to evaluate …

Objective Sepsis is one of the main causes of morbidity and mortality worldwide.
Microcirculatory impairment, especially damage to the endothelium and glycocalyx, is often …

OBJECTIVES: Cardiopulmonary bypass surgery is complicated by metabolic acidosis,
microvascular dysfunction, and capillary leak. The glycocalyx—a layer of proteins and …

Acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure yet has
few pharmacologic therapies, reflecting the mechanistic heterogeneity of lung injury. We …