Simple Summary The p53 family is a complex family of transcription factors with different
cellular functions that are involved in several physiological processes. A massive amount of …

In this article, we survey the major p53 (TP53) alterations identified in gastric carcinomas
and their precursors. These include p53 expression, mutations, and loss of heterozygosity …

The aim of this study was to clarify whether specific p53 mutations may have biological
relevance in terms of disease relapse or death in gastric carcinomas (GC). Resected …

Abstract p53 is a tumor suppressor gene whose mutation is highly associated with
tumorigenesis. The present study investigated the role of p53β in the inhibition of …

The p53 protein plays a central role in the prevention of tumorigenesis. Cellular stresses,
such as DNA damage and aberrant oncogene activation, trigger induction of p53 that halts …

Abstract p53R2, a recently identified putative tumor suppressor located at 8q23. 1, encodes
a protein with striking similarity to a small subunit of ribonucleotide reductase. p53R2 is …

Materials and methods Expression of tumor suppressor gene p53 was investigated
immunohistochemically in the primary lesion of 196 patients with advanced gastric cancers …

Mutations in the p53 gene, one of the most common genetic alterations in human cancer,
are implicated in tumorigenesis and tumour progression. Although p53 protein expression …

Intestinal metaplasia (IM) is a premalignant lesion associated with gastric cancer (GC) but is
poorly described in terms of molecular changes. Here, we explored the role of TP53, a …

While altered TP53 is the most frequent mutation in gastric cancer (GC), its association with
molecular or clinical phenotypes (eg, overall survival, disease-free survival) remains little …