Microglia are the first line of defense at the level of the central nervous system (CNS).
Phenotypic change in microglia can be regulated by various factors, including the orexin …

Alpha-tocopherol (vitamin E) is a plant-derived antioxidant that is essential for human health.
Studies with humans and with animal models of vitamin E deficiency established the critical …

Vitamin E is essential for neurological function. This fact, together with a growing body of
evidence indicating that neurodegenerative processes are associated with oxidative stress …

Since its discovery, vitamin E has been extensively researched by a large number of
investigators in an attempt to fully understand its role in a variety of pathophysiological …

Characterized by specific neuronal cell losses, neu‑rodegenerative diseases are among the
leading cause of disabilities in elderly people (Knight, 1997; Floyd and Hensley 2002 …

Vitamin E, comprising tocopherols and tocotrienols, is mainly known as an antioxidant. The
aim of this review is to summarize the molecular mechanisms and signaling pathways linked …

One of the characteristics of Alzheimer´ s disease (AD) is an increased amyloid load and an
enhanced level of reactive oxidative species (ROS). Vitamin E has known beneficial …

Microglia, the resident macrophage-like population in the central nervous system, play a
crucial role in the pathogenesis of many neurodegenerative disorders by triggering an …

This book chapter reviews the effects of vitamin E in intracellular signalling pathways in the
brain, focusing on its modulation of neuronal survival. It also discusses the protective role of …

Several pathological conditions are believed to be causally related to the generation of
reactive oxygen species and free radicals including various neurodegenerative disorders. In …