Noise exposure and distortion product otoacoustic emission suprathreshold amplitudes: a genome-wide association study

J Lavinsky, G Kasperbauer, RF Bento… - Audiology and …, 2021 - karger.com
Background: Although several candidate-gene association studies have been conducted to
investigate noise-induced hearing loss (NIHL) in humans, most are underpowered …

The genetic architecture of noise-induced hearing loss: evidence for a gene-by-environment interaction

J Lavinsky, M Ge, AL Crow, C Pan… - G3: Genes …, 2016 - academic.oup.com
The discovery of environmentally specific genetic effects is crucial to the understanding of
complex traits, such as susceptibility to noise-induced hearing loss (NIHL). We describe the …

Genome-Wide Association Study Identifies Nox3 as a Critical Gene for Susceptibility to Noise-Induced Hearing Loss

J Lavinsky, AL Crow, C Pan, J Wang, KA Aaron… - PLoS …, 2015 - journals.plos.org
In the United States, roughly 10% of the population is exposed daily to hazardous levels of
noise in the workplace. Twin studies estimate heritability for noise-induced hearing loss …

Untangling the genomics of noise-induced hearing loss and tinnitus: Contributions of Mus musculus and Homo sapiens

RE Clifford, R Hertzano, KK Ohlemiller - The Journal of the Acoustical …, 2019 - pubs.aip.org
Chronic noise exposure is a side-effect of the industrial age and mechanized warfare, and
noise-induced hearing loss (NIHL) is second only to age-related hearing impairment (ARHI) …

Genome-wide screening for genetic loci associated with noise-induced hearing loss

CH White, JD Ohmen, S Sheth, AF Zebboudj… - Mammalian …, 2009 - Springer
Noise-induced hearing loss (NIHL) is one of the more common sources of environmentally
induced hearing loss in adults. In a mouse model, Castaneous (CAST/Ei) is an inbred strain …

Machine learning model identifies genomic variation in noise-induced hearing loss via whole-exome sequencing

B Fan, G Wang, H Han, B Li, L Wang, C Qu, X Zhang… - 2022 - researchsquare.com
Noise-induced hearing loss (NIHL) is related to noise exposure and whether humans
suffered from NIHL is also related to different sensitivity to noise. Whole exome sequencing …

Genetics of noise-induced hearing loss in the mouse model

S Early, E Du, E Boussaty, R Friedman - Hearing Research, 2022 - Elsevier
Hearing loss is the most common sensory deficit worldwide, with the majority of preventable
injury attributed to noise-induced hearing loss (NIHL). Highly conserved cochlear genetics …

Screening of noise-induced hearing loss (NIHL)-associated SNPs and the assessment of its genetic susceptibility

X Zhang, Y Ni, Y Liu, L Zhang, M Zhang, X Fang… - Environmental …, 2019 - Springer
Background The aim of this study was to screen for noise-induced hearing loss (NIHL)-
associated single nucleotide polymorphisms (SNPs) and to construct genetic risk prediction …

Hearing loss and tinnitus: association studies for complex-hearing disorders in mouse and man

EC Boussaty, RA Friedman, Million Veteran Program… - Human genetics, 2022 - Springer
Genome-wide association studies (GWAS) provide an unbiased first look at genetic loci
involved in aging and noise-induced sensorineural hearing loss and tinnitus. The hearing …

Gene expression changes in chinchilla cochlea from noise-induced temporary threshold shift

RT Taggart, SL McFadden, DL Ding… - Noise and …, 2001 - journals.lww.com
Acoustic overstimulation produces many anatomical, biochemical and physiological
changes in the inner ear. However, the changes in gene expression that underlie these …