Cystic fibrosis patients suffer from a progressive, often fatal lung disease, which is based on
a complex interplay between chronic infections, locally accumulating immune cells and …

Background Idiopathic pulmonary fibrosis (IPF) is a chronically progressive interstitial lung
disease of unknown etiology. Previously, we have demonstrated the selective upregulation …

Elevated pulmonary levels of CCL18 have been associated with influx of T lymphocytes,
collagen accumulation, and a decline in lung function in pulmonary fibrosis patients. We …

We have previously shown that mice that are genetically deficient in the CCR2 gene
(CCR2−/− mice) are protected from fluorescein isothiocyanate (FITC)-induced lung fibrosis …

Accumulating evidence suggests that fibrosis is a multicellular process with contributions
from alveolar epithelial cells (AECs), recruited monocytes/macrophages, and fibroblasts. We …

Chronic lung disease determines the morbidity and mortality of cystic fibrosis (CF) patients.
The pulmonary immune response in CF is characterized by an early and non-resolving …

Rationale Recent data suggest that the localisation of airway epithelial cells in the distal
lung in idiopathic pulmonary fibrosis (IPF) may drive pathology. We set out to discover …

CF lung disease is characterized by a chronic and non-resolving activation of the innate
immune system with excessive release of chemokines/cytokines including IL-8 and …

Cystic fibrosis (CF) lung disease is characterised by chronic Pseudomonas aeruginosa
infection and leukocyte infiltration. Chemokines recruit leukocytes to sites of infection. Gene …

Abstract T helper 9 (Th9) cells contribute to lung inflammation and allergy as sources of
interleukin-9 (IL-9). However, the mechanisms by which IL-9/Th9 mediate immunopathology …