[HTML][HTML] m6A mRNA methylation is essential for oligodendrocyte maturation and CNS myelination

H Xu, Y Dzhashiashvili, A Shah, RB Kunjamma… - Neuron, 2020 - cell.com
The molecular mechanisms that govern the maturation of oligodendrocyte lineage cells
remain unclear. Emerging studies have shown that N 6-methyladenosine (m 6 A), the most …

m6A RNA Methylation Controls Neural Development and Is Involved in Human Diseases

K Du, L Zhang, T Lee, T Sun - Molecular neurobiology, 2019 - Springer
RNA modifications are involved in many aspects of biological functions. N6-
methyladenosine (m 6 A) is one of the most important forms of RNA methylation and plays a …

Epitranscriptomic m6A regulation following spinal cord injury

L Xing, Y Cai, T Yang, W Yu, M Gao… - Journal of …, 2021 - Wiley Online Library
RNA methylation is involved in multiple physiological and pathological processes. However,
the role of RNA methylation in spinal cord regeneration has not been reported. In this study …

[HTML][HTML] A novel m6A reader Prrc2a controls oligodendroglial specification and myelination

R Wu, A Li, B Sun, JG Sun, J Zhang, T Zhang, Y Chen… - Cell research, 2019 - nature.com
Abstract While N 6-methyladenosine (m6A), the most abundant internal modification in
eukaryotic mRNA, is linked to cell differentiation and tissue development, the biological …

[HTML][HTML] N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications

Y Wang, Y Li, M Yue, J Wang, S Kumar… - Nature …, 2018 - nature.com
Abstract Internal N 6-methyladenosine (m6A) modification is widespread in messenger
RNAs (mRNAs) and is catalyzed by heterodimers of methyltransferase-like protein 3 (Mettl3) …

[HTML][HTML] Temporal control of mammalian cortical neurogenesis by m6A methylation

KJ Yoon, FR Ringeling, C Vissers, F Jacob, M Pokrass… - Cell, 2017 - cell.com
Summary N 6-methyladenosine (m 6 A), installed by the Mettl3/Mettl14 methyltransferase
complex, is the most prevalent internal mRNA modification. Whether m 6 A regulates …

[HTML][HTML] The role of mRNA m6A methylation in the nervous system

J Li, X Yang, Z Qi, Y Sang, Y Liu, B Xu, W Liu, Z Xu… - Cell & bioscience, 2019 - Springer
Epitranscriptomics, also known as “RNA epigenetics”, is a chemical modification for RNA
regulation. Ribonucleic acid (RNA) methylation is considered to be a major discovery …

[HTML][HTML] Regulation of N6-methyladenosine (m6A) RNA methylation in microglia-mediated inflammation and ischemic stroke

F Zhang, Y Ran, M Tahir, Z Li, J Wang… - Frontiers in cellular …, 2022 - frontiersin.org
N6-methyladenosine (m6A) is the most abundant post-transcription modification, widely
occurring in eukaryotic mRNA and non-coding RNA. m6A modification is highly enriched in …

[HTML][HTML] Functional characterization of DNA methylation in the oligodendrocyte lineage

S Moyon, JL Huynh, D Dutta, F Zhang, D Ma, S Yoo… - Cell reports, 2016 - cell.com
Oligodendrocytes derive from progenitors (OPCs) through the interplay of epigenomic and
transcriptional events. By integrating high-resolution methylomics, RNA-sequencing, and …

Region-specific RNA m6A methylation represents a new layer of control in the gene regulatory network in the mouse brain

M Chang, H Lv, W Zhang, C Ma, X He… - Open …, 2017 - royalsocietypublishing.org
N6-methyladenosine (m6A) is the most abundant epitranscriptomic mark found on mRNA
and has important roles in various physiological processes. Despite the relatively high m6A …