As a major component of cell membrane lipids, Arachidonic acid (AA), being a major
component of the cell membrane lipid content, is mainly metabolized by three kinds of …

Recent studies indicate that arachidonic acid is primarily metabolized by cytochrome P450
enzymes of the 4A and 2C families in the kidney to 20-hydroxyeicosatetraenoic acid (HETE) …

Role of 20-hydroxyeicosatetraenoic acid and epoxyeicosatrien... : Current Opinion in
Nephrology and Hypertension Role of 20-hydroxyeicosatetraenoic acid and …

Arachidonic acid (AA), an n‐6 essential fatty acid, is a major component of mammalian cells
and can be released by phospholipase A2. Accumulating evidence indicates that AA plays …

Thirty-five years ago, a third pathway for the metabolism of arachidonic acid by cytochrome
P450 enzymes emerged. Subsequent work revealed that 20-hydroxyeicosatetraenoic and …

Small lipids such as eicosanoids exert diverse and complex functions. In addition to their
role in regulating normal kidney function, these lipids also play important roles in the …

Rat kidney cortical and medullary microsomal fractions catalyzed cytochrome P-450-linked
metabolism of arachidonic acid (AA) to epoxyeicosatrienoic acids (EETs)(56+/-6% of total …

Arachidonic acid metabolites are vital for the proper control of renal haemodynamics and,
when not properly controlled, can contribute to renal vascular injury and end-stage renal …

Arachidonic acid can be metabolized by cytochrome P450 (CYP450) enzymes to 5, 6-, 8, 9-,
11, 12-, and 14, 15-epoxyeicosatrienoic acids (EETs), their corresponding …

20-Hydroxyeicosatetraenoic acid (20-HETE), an ω-hydroxylated arachidonic acid (AA)
metabolite, elicits specific effects on kidney vascular and tubular function that, in turn …