The incretin system ABCs in obesity and diabetes–novel therapeutic strategies for weight loss and beyond
Incretins are gastrointestinal‐derived hormones released in response to a meal playing a
key role in the regulation of postprandial secretion of insulin (incretin effect) and glucagon by …
key role in the regulation of postprandial secretion of insulin (incretin effect) and glucagon by …
The incretin pathway as a new therapeutic target for obesity
TM Barber, H Begbie, J Levy - Maturitas, 2010 - Elsevier
The global obesity epidemic fuelled by our obesogenic environment, and the prevention and
treatment of obesity are some of the most important health-care challenges of our time …
treatment of obesity are some of the most important health-care challenges of our time …
Incretins in obesity and diabetes
CW Chia, JM Egan - Annals of the New York Academy of …, 2020 - Wiley Online Library
Incretins are hormones secreted from enteroendocrine cells after nutrient intake that
stimulate insulin secretion from β cells in a glucose‐dependent manner. Glucose …
stimulate insulin secretion from β cells in a glucose‐dependent manner. Glucose …
Update on incretin hormones
LK Phillips, JB Prins - Annals of the New York Academy of …, 2011 - Wiley Online Library
The incretin hormones glucagon‐like‐peptide‐1 (GLP‐1) and glucose‐dependent
insulinotropic polypeptide (GIP) are released from the intestine following oral ingestion of …
insulinotropic polypeptide (GIP) are released from the intestine following oral ingestion of …
Is there a place for incretin therapies in obesity and prediabetes?
JJ Holst, CF Deacon - Trends in Endocrinology & Metabolism, 2013 - cell.com
Incretin-based therapies exploit the insulinotropic actions of the gut hormones gastric
inhibitory peptide (GIP) and glucagon-like peptide-1 (GLP-1) for the treatment of diabetes …
inhibitory peptide (GIP) and glucagon-like peptide-1 (GLP-1) for the treatment of diabetes …
[HTML][HTML] Incretin hormones in obesity and related cardiometabolic disorders: the clinical perspective
J Michałowska, E Miller-Kasprzak, P Bogdański - Nutrients, 2021 - mdpi.com
The prevalence of obesity continues to grow rapidly worldwide, posing many public health
challenges of the 21st century. Obese subjects are at major risk for serious diet-related …
challenges of the 21st century. Obese subjects are at major risk for serious diet-related …
Biology of incretins: GLP-1 and GIP
LL Baggio, DJ Drucker - Gastroenterology, 2007 - Elsevier
This review focuses on the mechanisms regulating the synthesis, secretion, biological
actions, and therapeutic relevance of the incretin peptides glucose-dependent insulinotropic …
actions, and therapeutic relevance of the incretin peptides glucose-dependent insulinotropic …
The role of incretins in glucose homeostasis and diabetes treatment
W Kim, JM Egan - Pharmacological reviews, 2008 - ASPET
Incretins are gut hormones that are secreted from enteroendocrine cells into the blood within
minutes after eating. One of their many physiological roles is to regulate the amount of …
minutes after eating. One of their many physiological roles is to regulate the amount of …
[HTML][HTML] Recent advances in incretin-based pharmacotherapies for the treatment of obesity and diabetes
The incretin hormone glucagon-like peptide-1 (GLP-1) has received enormous attention
during the past three decades as a therapeutic target for the treatment of obesity and type 2 …
during the past three decades as a therapeutic target for the treatment of obesity and type 2 …
[HTML][HTML] The expanding incretin universe: from basic biology to clinical translation
DJ Drucker, JJ Holst - Diabetologia, 2023 - Springer
Incretin hormones, principally glucose-dependent insulinotropic polypeptide (GIP) and
glucagon-like peptide-1 (GLP-1), potentiate meal-stimulated insulin secretion through direct …
glucagon-like peptide-1 (GLP-1), potentiate meal-stimulated insulin secretion through direct …