Spinal cord stimulation is a proven effective therapy for treating chronic neuropathic pain.
Previous work in our laboratory demonstrated that spinal cord stimulation based on a …

While numerous studies and patient experiences have demonstrated the efficacy of spinal
cord stimulation as a treatment for chronic neuropathic pain, the exact mechanism …

The development and maintenance of chronic neuropathic pain involves distorted neuroglial
interactions, which result in prolonged perturbations of immune and inflammatory response …

Glial cells play an essential role in maintaining the proper functioning of the nervous system.
They are more abundant than neurons in most neural tissues and provide metabolic and …

Background Few studies have evaluated single-gene changes modulated by spinal cord
stimulation (SCS), providing a narrow understanding of molecular changes. Genomics …

The effect of spinal cord stimulation (SCS) using differential target multiplexed programming
(DTMP) on proteins involved in the regulation of ion transport in spinal cord (SC) tissue of an …

Spinal cord stimulation has become an important modality in pain treatment especially for
neuropathic pain conditions refractory to pharmacotherapy. However, the molecular control …

Neuropathic pain, especially that resulting from spinal cord injury, is a tremendous clinical
challenge. A myriad of biological changes have been implicated in producing these pain …

Objectives Spinal cord stimulation (SCS) provides relief for patients suffering from chronic
neuropathic pain although its mechanism may not be as dependent on electrical …

Second-order spinal cord excitatory neurons play a key role in spinal processing and
transmission of pain signals to the brain. Exogenously induced change in developmentally …