Predictive Power of Cognitive Biomarkers in Neurodegenerative Disease Drug Development: Utility of the P300 Event‐Related Potential
J Olichney, J Xia, KJ Church, HJ Moebius - Neural Plasticity, 2022 - Wiley Online Library
Neurodegenerative diseases, such as Alzheimer's disease (AD), and their associated
deterioration of cognitive function are common causes of disability. The slowly developing …
deterioration of cognitive function are common causes of disability. The slowly developing …
Cognitive event-related potentials: useful clinical information in Alzheimer's disease
E Katada, K Sato, K Ojika… - Current Alzheimer …, 2004 - ingentaconnect.com
Cognitive event-related potentials (ERPs) have been used as a marker of cognitive function
in patients with psychiatric and neurological disorders. In particular, the P300 potential has …
in patients with psychiatric and neurological disorders. In particular, the P300 potential has …
Brain ERP components predict which individuals progress to Alzheimer's disease and which do not
RM Chapman, JW McCrary, MN Gardner… - Neurobiology of …, 2011 - Elsevier
Predicting which individuals will progress to Alzheimer's disease (AD) is important in both
clinical and research settings. We used brain Event-Related Potentials (ERPs) obtained in a …
clinical and research settings. We used brain Event-Related Potentials (ERPs) obtained in a …
[HTML][HTML] P300 and neuropsychological assessment in mild cognitive impairment and Alzheimer dementia
Only a small proportion of individuals with Mild Cognitive Impairment (MCI) will convert to
dementia. Methods currently available to identify risk for conversion do not combine enough …
dementia. Methods currently available to identify risk for conversion do not combine enough …
Neuropsychological correlates of the P300 in patients with Alzheimer's disease
OBJECTIVES: The P300 is a useful psychophysiological index that reflects cognitive
functions; however, the relationship between P300 indices and neuropsychological tests in …
functions; however, the relationship between P300 indices and neuropsychological tests in …
The role of event-related potentials in cognitive decline in Alzheimer's disease
CL Lai, RT Lin, LM Liou, CK Liu - Clinical Neurophysiology, 2010 - Elsevier
OBJECTIVES: Early diagnosis and monitoring of disease progression have become vital in
clinical practice as disease modifying treatments for Alzheimer's disease (AD) become …
clinical practice as disease modifying treatments for Alzheimer's disease (AD) become …
[HTML][HTML] Revolutionizing Alzheimer's disease and clinical trials through biomarkers
N Mattsson, MC Carrillo, RA Dean… - Alzheimer's & Dementia …, 2015 - Elsevier
Abstract The Alzheimer's Association's Research Roundtable met in May 2014 to explore
recent progress in developing biomarkers to improve understanding of disease …
recent progress in developing biomarkers to improve understanding of disease …
Value of event‐related P300 subcomponents in the clinical diagnosis of mild cognitive impairment and Alzheimer's disease
Accurate and early diagnosis of Alzheimer's Disease (AD) with reliable and noninvasive
methods is of great importance for clinical practice as effective and specific antidementive …
methods is of great importance for clinical practice as effective and specific antidementive …
[HTML][HTML] Associations of event-related brain potentials and Alzheimer's disease severity: A longitudinal study
W Fruehwirt, G Dorffner, S Roberts… - Progress in Neuro …, 2019 - Elsevier
Background So far, no cost-efficient, widely-used biomarkers have been established to
facilitate the objectivization of Alzheimer's disease (AD) diagnosis and monitoring. Research …
facilitate the objectivization of Alzheimer's disease (AD) diagnosis and monitoring. Research …
[HTML][HTML] Biomarkers for evaluation of clinical efficacy of multipotential neuroprotective drugs for Alzheimer's and Parkinson's diseases
I Halperin, M Morelli, AD Korczyn, MBH Youdim… - …, 2009 - Elsevier
During the last century, the world population has shown a staggering increase in its
proportion of elderly members and thus neurodegenerative diseases like Alzheimer's …
proportion of elderly members and thus neurodegenerative diseases like Alzheimer's …