Predictive Power of Cognitive Biomarkers in Neurodegenerative Disease Drug Development: Utility of the P300 Event‐Related Potential

J Olichney, J Xia, KJ Church, HJ Moebius - Neural Plasticity, 2022 - Wiley Online Library
Neurodegenerative diseases, such as Alzheimer's disease (AD), and their associated
deterioration of cognitive function are common causes of disability. The slowly developing …

Cognitive event-related potentials: useful clinical information in Alzheimer's disease

E Katada, K Sato, K Ojika… - Current Alzheimer …, 2004 - ingentaconnect.com
Cognitive event-related potentials (ERPs) have been used as a marker of cognitive function
in patients with psychiatric and neurological disorders. In particular, the P300 potential has …

Brain ERP components predict which individuals progress to Alzheimer's disease and which do not

RM Chapman, JW McCrary, MN Gardner… - Neurobiology of …, 2011 - Elsevier
Predicting which individuals will progress to Alzheimer's disease (AD) is important in both
clinical and research settings. We used brain Event-Related Potentials (ERPs) obtained in a …

[HTML][HTML] P300 and neuropsychological assessment in mild cognitive impairment and Alzheimer dementia

MA Parra, LL Ascencio, HF Urquina, F Manes… - Frontiers in …, 2012 - frontiersin.org
Only a small proportion of individuals with Mild Cognitive Impairment (MCI) will convert to
dementia. Methods currently available to identify risk for conversion do not combine enough …

Neuropsychological correlates of the P300 in patients with Alzheimer's disease

MS Lee, SH Lee, EO Moon, YJ Moon, S Kim… - Progress in Neuro …, 2013 - Elsevier
OBJECTIVES: The P300 is a useful psychophysiological index that reflects cognitive
functions; however, the relationship between P300 indices and neuropsychological tests in …

The role of event-related potentials in cognitive decline in Alzheimer's disease

CL Lai, RT Lin, LM Liou, CK Liu - Clinical Neurophysiology, 2010 - Elsevier
OBJECTIVES: Early diagnosis and monitoring of disease progression have become vital in
clinical practice as disease modifying treatments for Alzheimer's disease (AD) become …

[HTML][HTML] Revolutionizing Alzheimer's disease and clinical trials through biomarkers

N Mattsson, MC Carrillo, RA Dean… - Alzheimer's & Dementia …, 2015 - Elsevier
Abstract The Alzheimer's Association's Research Roundtable met in May 2014 to explore
recent progress in developing biomarkers to improve understanding of disease …

Value of event‐related P300 subcomponents in the clinical diagnosis of mild cognitive impairment and Alzheimer's disease

T Frodl, H Hampel, G Juckel, K Bürger… - …, 2002 - Wiley Online Library
Accurate and early diagnosis of Alzheimer's Disease (AD) with reliable and noninvasive
methods is of great importance for clinical practice as effective and specific antidementive …

[HTML][HTML] Associations of event-related brain potentials and Alzheimer's disease severity: A longitudinal study

W Fruehwirt, G Dorffner, S Roberts… - Progress in Neuro …, 2019 - Elsevier
Background So far, no cost-efficient, widely-used biomarkers have been established to
facilitate the objectivization of Alzheimer's disease (AD) diagnosis and monitoring. Research …

[HTML][HTML] Biomarkers for evaluation of clinical efficacy of multipotential neuroprotective drugs for Alzheimer's and Parkinson's diseases

I Halperin, M Morelli, AD Korczyn, MBH Youdim… - …, 2009 - Elsevier
During the last century, the world population has shown a staggering increase in its
proportion of elderly members and thus neurodegenerative diseases like Alzheimer's …