Preparation of drug nanoparticles via wet media milling (nanomilling) is a very versatile drug
delivery platform and is suitable for oral, injectable, inhalable, and buccal applications. Wet …

A significant percentage of active pharmaceutical ingredients identified through discovery
screening programs is poorly soluble in water. These molecules are often difficult to …

Milling involves the application of mechanical energy to physically break down coarse
particles to finer ones and is regarded as a “top–down” approach in the production of fine …

Wet media milling is a popular technology used to prepare nanosuspensions. However, the
theories and methods to guide the research on the formulation and process affecting wet …

Wet media milling by top down method has proved to be an effective method to prepare
nanosuspension of poorly soluble drugs/APIs. Few or no attempts have been made so far to …

Wet stirred media milling has proven to be a robust process for producing nanoparticle
suspensions of poorly water-soluble drugs. As the process is expensive and energy …

Objectives Wet milling is a common technique to produce drug nanocrystals. Stability of the
nanocrystals is a critical question, and different kinds of stabilizers, eg polymers, celluloses …

Micronization and nanoparticle production of poorly water-soluble drugs was investigated
using single wet milling equipment operating in the attritor and stirred media modes. The …

Nanoparticles of BCS Class II drugs are produced in wet stirred media mills operating in
batch or recirculation mode with the goal of resolving the poor water-solubility issue. Scant …

Drug nanoparticles embedded in a dispersant matrix as a secondary phase, ie, drug-laden
nanocomposites, offer a versatile delivery platform for enhancing the dissolution rate and …