Background The reportedly high mutation rate of mitochondrial DNA (mtDNA) may be
attributed to the absence of histone protection and complete repair mechanisms …

Heteroplasmic mitochondrial DNA (mtDNA) mutations are a common cause of inherited
disease, but a few recurrent mutations account for the vast majority of new families. The …

Background: Ovarian tumour is the second most common form of cancer affecting female
reproductive system and the most lethal of the gynaecological malignancies. Since past …

Inheritance of the mitochondrial genome does not follow the rules of conventional
Mendelian genetics. The mitochondrial DNA (mtDNA) is present in many copies per cell and …

Mitochondria play a fundamental role during development of the female germline. They are
fragmented, round, and small. Despite these characteristics suggesting that they are …

Mitochondrial DNA (mtDNA) is predominately uniparentally transmitted. This results in
organisms with a single type of mtDNA (homoplasmy), but two or more mtDNA haplotypes …

Mitochondrial DNA (mtDNA) disorders are recognized as one of the most common causes of
inherited metabolic disorders. The mitochondrial genome occurs in multiple copies resulting …

Background Epithelial ovarian cancer (EOC) heavily relies on oxidative phosphorylation
(OXPHOS) and exhibits distinct mitochondrial metabolic reprogramming. Up to now, the …

Mitochondria, mainly known as energy factories of eukaryotic cells, also exert several
additional signaling and metabolic functions and are today recognized as major cellular …

Mitochondria are integral to energy production, but their role in reproduction is multifaceted.
They regulate germ cell fate and ensure the lineage's continuity, acting as gatekeepers of …