The findings reviewed in this article expand our understanding of the relevance of elevated
plasma oxalate levels leading to inflammasome activation. We propose that inhibiting …

Inflammasomes are multiprotein complexes with an important role in the innate immune
response. Canonical activation of inflammasomes results in caspase-1 activation and …

Therapies aiming to decrease uric acid levels prevent renal NLRP3 inflammasome
activation and exert renoprotective effects in experimental kidney diseases. However, further …

High levels of aldosterone impair renal function by activating proinflammatory and profibrotic
pathways. However, the molecular mechanism underlying aldosterone‐induced …

Background and Purpose Inflammasomes are multimeric complexes that facilitate caspase‐
1‐mediated processing of the pro‐inflammatory cytokines IL‐1β and IL‐18. Clinical …

Background: The intracellular multiprotein complex termed the inflammasome functions as a
platform of pro-inflammatory cytokine production such as IL-1β and IL-18. Under certain …

Renal reactive oxygen species (ROS) and mononuclear leukocyte infiltration are involved in
the progressive stage (exacerbation) of IgA nephropathy (IgAN), which is characterized by …

Oxalate is an ionic form of a potentially toxic oxalic acid that is formed in the human body
from a combination of food sources and their absorption in the gastrointestinal tract …

For end‐stage renal disease (ESRD) patients, cardiovascular disease remains the single
most common cause of excess morbidity and mortality. Furthermore, although the …

Hypertension causes vascular complications, such as stroke, cardiovascular disease, and
chronic kidney disease (CKD). The relationship between endothelial dysfunction and …