Cancer cells, including melanoma cells, often metastasize regionally through the lymphatic
system before metastasizing systemically through the blood,,–; however, the reason for this …

Cancer immunotherapy restores or enhances the effector function of CD8+ T cells in the
tumour microenvironment,. CD8+ T cells activated by cancer immunotherapy clear tumours …

Ferroptosis is a non-apoptotic form of regulated cell death that is triggered by the
discoordination of regulatory redox mechanisms culminating in massive peroxidation of …

Solid cancer cells commonly enter the blood and disseminate systemically, but are highly
inefficient at forming distant metastases for poorly understood reasons. Here we studied …

Ferroptosis, a cell death process driven by cellular metabolism and iron-dependent lipid
peroxidation, has been implicated in diseases such as ischaemic organ damage and …

Inflammation lights the way to metastasis | Nature Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the best …

Plasticity of the cell state has been proposed to drive resistance to multiple classes of cancer
therapies, thereby limiting their effectiveness,,,. A high-mesenchymal cell state observed in …

In a recent study published in Cancer Cell, Liao et al. 1 identified CD8+ T-cell-derived
interferon (IFN) γ in combination with polyunsaturated fatty acids (PUFAs) as a natural …

Immunogenic cell death significantly contributes to the success of anti-cancer therapies, but
immunogenicity of different cell death modalities widely varies. Ferroptosis, a form of cell …

Intermittent intense ultraviolet (UV) exposure represents an important aetiological factor in
the development of malignant melanoma. The ability of UV radiation to cause tumour …