Published in 1988: The enormous literature, scattered through journals devoted to
physiology, biochemistry, pharmacology, ultrastructure, and clinical medicine, together with …

Diabetes is a major public health problem which is expected to affect 160 million people
worldwide by the year 2000. Clearly an understanding of the effects of diabetes on the heart …

Numerous clinical and epidemiological reports have confirmed that human diabetics appear
particularly susceptible to heart failure, which is a leading cause of death in these …

Diabetes mellitus is associated with a specific cardiomyopathy. This is evident from the
clinical-pathological work and the epidemiologic data from the Framingham study …

Epidemiological data reviewed suggest that diabetes itself increases the cardiac risk of
diabetics (types I and II), independently from the development of coronary heart disease and …

The use of insulin by diabetics has largely removed the threat of death from ketotic coma but
cardiovascular dysfunction remains a major cause of death in patients with diabetes. Recent …

The incidence of mortality from cardiovascular disease is higher in diabetic patients. Since a
significant percentage of the general population is affected by diabetes and a large …

The concept of a “diabetic cardiomyopathy” has been invoked to explain the higher than
expected occurrence of congestive heart failure (CHF) in subjects with diabetes (1, 2) …

ular hypertrophy and increased heart mass, with mildly reduced left ventricular systolic
performance. 22 On the microscopic level, histological studies of autopsy and biopsy …

Patients with diabetes mellitus are particularly vulnerable to cardiovascular disease.
Although both the macrovascular and microvascular complications are present in patients …