Purpose The adoptive transfer of in vitro generated tumor antigen-specific cytotoxic T
lymphocytes (CTL) provides a promising approach to the immunotherapy of cancer. A phase …

Tumor antigens that might serve as potential targets for adoptive T-cell therapy have been
defined in different tumor entities, especially in malignant melanoma. To generate conditions …

Abstract A phase I/II study was conducted to test the feasibility and safety of the adoptive
transfer of tumor-reactive T cells and daily injections of interferon-alpha (IFNα) in metastatic …

Adoptive T cell therapy has been successfully used for treatment of viral and malignant
diseases. However, little is known about the fate and trafficking of transferred Ag-specific T …

Adoptive T cell therapy, involving the ex vivo selection and expansion of antigen-specific T
cell clones, provides a means of augmenting antigen-specific immunity without the in vivo …

This report describes a phase I study of the adoptive transfer of cloned melanoma antigen–
specific T lymphocytes for therapy of patients with advanced melanoma. Clones were …

Immunotherapy by adoptive T-cell transfer aims at maximizing tumor antigen-specific T-cell
responses. We treated 14 patients at the metastatic stage in a phase II study with Melan-A …

Cancer vaccines can induce the in vivo generation of tumor Ag-specific T cells in patients
with metastatic melanoma yet seldom elicit objective clinical responses. Alternatively …

In this study, we report the adoptive transfer of highly tumor-reactive Melan-A-specific T cell
clones to patients with metastatic melanoma, and the follow-up of these injected cells. These …

Adoptive cell therapy (ACT) using tumor-infiltrating lymphocytes (TIL) for metastatic
melanoma has shown objective response rates as high as 72%. The successful application …