Abstract Background/Aims: Vascular relaxation caused by Triiodothyronine (T3) involves
direct activation of endothelial cells (EC) and vascular smooth muscle cells (VSMC) …

Vascular dysfunction associated with hypertension comprises hypercontractility and
impaired vasodilation. We have previously demonstrated that triiodothyronine (T3), the …

Aims Thyroid hormone (TH) rapidly relaxes vascular smooth muscle cells (VSMCs).
However, the mechanisms involved in this effect remain unclear. We hypothesize that TH …

Objective: Hyperthyroidism has pronounced effects on vascular function and endothelium-
dependent relaxation. The aim of the present study was to identify mechanisms underlying …

Hyperthyroidism is characterized by increased vascular relaxation and decreased vascular
contraction and is associated with augmented levels of triiodothyronine (T3) that contribute …

The enhanced cardiovascular hemodynamics associated with triiodo-l-thyronine (T3)
treatment is in part mediated by a decrease in systemic vascular resistance. To determine …

Context Hypothyroidism impairs cardiovascular health and contributes to endothelial
dysfunction with reduced vasodilation. How 3, 5, 3′-triiodothyronine (T3) and its receptors …

Hypothyroidism is associated with elevated levels of serum thyrotropin (TSH), which have
been shown to promote abnormal proliferation of vascular smooth muscle cells and …

Transient receptor potential vanilloid channel 4 (TRPV4) is a polymodally activated
nonselective cationic channel implicated in the regulation of vasodilation and hypertension …

Context: Thyroid hormone regulates several cardiovascular functions, and low T3 levels are
frequently associated with cardiovascular diseases. Whether T3 exerts any acute and direct …