Using pharmacological manipulations to study the role of dopamine in human reward functioning: A review of studies in healthy adults

HE Webber, P Lopez-Gamundi, SN Stamatovich… - Neuroscience & …, 2021 - Elsevier
Dopamine (DA) plays a key role in reward processing and is implicated in psychological
disorders such as depression, substance use, and schizophrenia. The role of DA in reward …

The “highs and lows” of the human brain on dopaminergics: Evidence from neuropharmacology

D Martins, MA Mehta, D Prata - Neuroscience & Biobehavioral Reviews, 2017 - Elsevier
Rewards are appetitive events that elicit approach. Ground-breaking findings from
neurophysiological experiments in animals, alongside neuropharmacology and …

The role of dopamine in reward and pleasure behaviour–review of data from preclinical research

RA Bressan, JA Crippa - Acta Psychiatrica Scandinavica, 2005 - Wiley Online Library
Objective: The purpose of this article is to review some of the basic aspects of the
dopaminergic system and its role in reward and pleasure behaviour. We also discuss the …

Dopaminergic modulation of the human reward system: a placebo-controlled dopamine depletion fMRI study

F da Silva Alves, N Schmitz, M Figee… - Journal of …, 2011 - journals.sagepub.com
Reward related behaviour is linked to dopaminergic neurotransmission. Our aim was to gain
insight into dopaminergic involvement in the human reward system. Combining functional …

[HTML][HTML] Advances in studying phasic dopamine signaling in brain reward mechanisms

RJ Wickham, W Solecki, LR Rathbun… - … in bioscience (Elite …, 2013 - ncbi.nlm.nih.gov
The last sixty years of research have provided extraordinary advances of our knowledge of
the reward system. Since its initial discovery as a neurotransmitter by Carlsson and …

The dopamine augmenter L-DOPA does not affect positive mood in healthy human volunteers

J Liggins, RO Pihl, C Benkelfat, M Leyton - PLoS One, 2012 - journals.plos.org
Dopamine neurotransmission influences approach toward rewards and reward-related
cues. The best cited interpretation of this effect proposes that dopamine mediates the …

Single dose of a dopamine agonist impairs reinforcement learning in humans: behavioral evidence from a laboratory-based measure of reward responsiveness

DA Pizzagalli, AE Evins, EC Schetter, MJ Frank… - …, 2008 - Springer
Rationale The dopaminergic system, particularly D2-like dopamine receptors, has been
strongly implicated in reward processing. Animal studies have emphasized the role of …

The role of dopamine in human addiction: from reward to motivated attention

IHA Franken, J Booij, W van den Brink - European journal of pharmacology, 2005 - Elsevier
There is general consensus among preclinical researchers that dopamine plays an
important role in the development and persistence of addiction. However, the precise role of …

Striatal dopamine transmission in healthy humans during a passive monetary reward task

HS Hakyemez, A Dagher, SD Smith, DH Zald - Neuroimage, 2008 - Elsevier
Research on dopamine (DA) transmission has emphasized the importance of increased
phasic DA cell firing in the presence of unpredictable rewards. Using [11C] raclopride PET …

The dopamine hypothesis of reward: past and current status

R Spanagel, F Weiss - Trends in neurosciences, 1999 - cell.com
Mesolimbic dopaminergic neurons are thought to serve as a final common neural pathway
for mediating reinforcement processes. However, several recent findings have challenged …