Cancer is one of the main causes of death worldwide. Despite the significant development of
methods of cancer healing during the past decades, chemotherapy still remains the main …

Background The acquisition of resistance to chemotherapy is a major hurdle in the
successful application of cancer therapy. Several anticancer approaches, including …

Multidrug resistance (MDR) continues to be a major challenge to effective chemotherapeutic
interventions against cancer. Various types of cancers have been observed to exhibit this …

The ability of cancer cells to become cross-resistant to structurally and functionally unrelated
anti-cancer drugs is known as multidrug resistance. It has been recognized that multidrug …

Anticancer drugs resistance is a complex process that arises from altering in the drug
targets. Advances in the DNA microarray, proteomics technology and the development of …

Chemotherapy is one of the important methods to treat cancer, and the emergence of
multidrug resistance (MDR) is one major cause for the failure of cancer chemotherapy …

The effectiveness of chemotherapy is one of the main challenges in cancer treatment and
resistance to classic drugs and traditional treatment processes is an obstacle to this goal …

Chemotherapy is the main strategy for the treatment of cancer. However, the main problem
limiting the success of chemotherapy is the development of multidrug resistance. The …

Although various mechanisms involved in anticancer multidrug resistance (MDR) can be
identified, it remains a major problem in oncology. Beyond that, the introduction of new …

The risk of acquisition of resistance to chemotherapy remains a major hurdle in the
management of various types of cancer patients. Several cellular and noncellular …