Dissolution challenges associated with the surface pH of drug particles: integration into mechanistic oral absorption modeling
B Hens, N Seegobin, M Bermejo, Y Tsume, N Clear… - The AAPS Journal, 2022 - Springer
The present work aimed to differentiate between in vitro dissolution profiles of ibuprofen as
input for GastroPlus™ and to see the impact on systemic exposure. In vitro dissolution …
input for GastroPlus™ and to see the impact on systemic exposure. In vitro dissolution …
Harmonizing biopredictive methodologies through the Product Quality Research Institute (PQRI) Part I: biopredictive dissolution of ibuprofen and dipyridamole tablets
Y Tsume, L Ashworth, M Bermejo, J Cheng, V Cicale… - The AAPS Journal, 2023 - Springer
Assessing in vivo performance to inform formulation selection and development decisions is
an important aspect of drug development. Biopredictive dissolution methodologies for oral …
an important aspect of drug development. Biopredictive dissolution methodologies for oral …
Best practices for integration of dissolution data into physiologically based biopharmaceutics models (PBBM): a biopharmaceutics modeling scientist perspective
Dissolution is considered as a critical input into physiologically based biopharmaceutics
models (PBBM) as it governs in vivo exposure. Despite many workshops, initiatives by …
models (PBBM) as it governs in vivo exposure. Despite many workshops, initiatives by …
Exploring clinically relevant dissolution specifications for oral solid dosage forms of weak acid drugs using an in silico modeling and simulation approach
A Kambayashi, C Yomota - European Journal of Pharmaceutical Sciences, 2021 - Elsevier
The aim of this study was to explore clinically relevant dissolution specifications for weak
acid drugs using an in silico drug absorption model. Loxoprofen sodium and ibuprofen were …
acid drugs using an in silico drug absorption model. Loxoprofen sodium and ibuprofen were …
Current status and future opportunities for incorporation of dissolution data in PBPK modeling for pharmaceutical development and regulatory applications: OrBiTo …
M Jamei, B Abrahamsson, J Brown, J Bevernage… - European Journal of …, 2020 - Elsevier
In vitro dissolution experiments are used to qualitatively assess the impact of formulation
composition and process changes on the drug dosage form performance. However, the use …
composition and process changes on the drug dosage form performance. However, the use …
Progressive tools and critical strategies for development of best fit PBPK model aiming better in vitro-in vivo correlation
Nowadays, conducting discriminative dissolution experiments employing physiologically
based pharmacokinetic modeling (PBPK) or physiologically based biopharmaceutical …
based pharmacokinetic modeling (PBPK) or physiologically based biopharmaceutical …
Drug dissolution in oral drug absorption: workshop report
K Raines, P Agarwal, P Augustijns, A Alayoubi, L Attia… - The AAPS Journal, 2023 - Springer
The in-person workshop “Drug Dissolution in Oral Drug Absorption” was held on May 23–
24, 2023, in Baltimore, MD, USA. The workshop was organized into lectures and breakout …
24, 2023, in Baltimore, MD, USA. The workshop was organized into lectures and breakout …
Mechanistic models for USP2 dissolution apparatus, including fluid hydrodynamics and sedimentation
X Pepin, M Goetschy, S Abrahmsén-Alami - Journal of Pharmaceutical …, 2022 - Elsevier
Drug product dissolution is a key input to Physiologically Based Biopharmaceutics Models
(PBBM) to be able to predict in vivo dissolution. The integration of product dissolution in …
(PBBM) to be able to predict in vivo dissolution. The integration of product dissolution in …
Mechanistic deconvolution of oral absorption model with dynamic gastrointestinal fluid to predict regional rate and extent of GI drug dissolution
Multiple approaches such as mathematical deconvolution and mechanistic oral absorption
models have been used to predict in vivo drug dissolution in the gastrointestinal (GI) tract …
models have been used to predict in vivo drug dissolution in the gastrointestinal (GI) tract …
Linking the gastrointestinal behavior of ibuprofen with the systemic exposure between and within humans—part 2: fed state
Exploring the intraluminal behavior of an oral drug product in the human gastrointestinal (GI)
tract remains challenging. Many in vivo techniques are available to investigate the impact of …
tract remains challenging. Many in vivo techniques are available to investigate the impact of …