Nonregistration, discontinuation, and nonpublication of randomized trials: A repeated metaresearch analysis
Background We previously found that 25% of 1,017 randomized clinical trials (RCTs)
approved between 2000 and 2003 were discontinued prematurely, and 44% remained …
approved between 2000 and 2003 were discontinued prematurely, and 44% remained …
Discontinuation and non-publication of randomised clinical trials supported by the main public funding body in Switzerland: a retrospective cohort study
A Amstutz, S Schandelmaier, R Frei, J Surina… - BMJ open, 2017 - bmjopen.bmj.com
Objective The Swiss National Science Foundation (SNSF) promotes academic excellence
through competitive selection of study proposals and rigorous evaluation of feasibility, but …
through competitive selection of study proposals and rigorous evaluation of feasibility, but …
Comparison between publicly accessible publications, registries, and protocols of phase III trials indicated persistence of selective outcome reporting
S Zhang, F Liang, W Li - Journal of clinical epidemiology, 2017 - Elsevier
Objectives The decision to make protocols of phase III randomized controlled trials (RCTs)
publicly accessible by leading journals was a landmark event in clinical trial reporting. Here …
publicly accessible by leading journals was a landmark event in clinical trial reporting. Here …
Non-publication of large randomized clinical trials: cross sectional analysis
Objective To estimate the frequency with which results of large randomized clinical trials
registered with ClinicalTrials. gov are not available to the public. Design Cross sectional …
registered with ClinicalTrials. gov are not available to the public. Design Cross sectional …
Extent of non-publication in cohorts of studies approved by research ethics committees or included in trial registries
C Schmucker, LK Schell, S Portalupi, P Oeller… - PloS one, 2014 - journals.plos.org
Background The synthesis of published research in systematic reviews is essential when
providing evidence to inform clinical and health policy decision-making. However, the …
providing evidence to inform clinical and health policy decision-making. However, the …
Prevalence, characteristics, and publication of discontinued randomized trials
Importance The discontinuation of randomized clinical trials (RCTs) raises ethical concerns
and often wastes scarce research resources. The epidemiology of discontinued RCTs …
and often wastes scarce research resources. The epidemiology of discontinued RCTs …
Is there a solution to publication bias? Researchers call for changes in dissemination of clinical research results
Objectives To explore opinions of authors of published reports of clinical trials and Cochrane
systematic reviews on the causes and methods of preventing publication bias. Study Design …
systematic reviews on the causes and methods of preventing publication bias. Study Design …
Research without results: inadequate public reporting of clinical trial results
RK Gopal, TE Yamashita, AV Prochazka - Contemporary clinical trials, 2012 - Elsevier
OBJECTIVE: In order to increase transparency in the medical literature, the Food and Drug
Administration (FDA) Modernization Act of 1997 and the FDA Amendment Act of 2007 …
Administration (FDA) Modernization Act of 1997 and the FDA Amendment Act of 2007 …
Comparison of registered and published outcomes in randomized controlled trials: a systematic review
CW Jones, LG Keil, WC Holland, MC Caughey… - BMC medicine, 2015 - Springer
Background Clinical trial registries can improve the validity of trial results by facilitating
comparisons between prospectively planned and reported outcomes. Previous reports on …
comparisons between prospectively planned and reported outcomes. Previous reports on …
Undisclosed changes in outcomes in randomized controlled trials: an observational study
R Ewart, H Lausen, N Millian - The Annals of Family Medicine, 2009 - Annals Family Med
PURPOSE We wanted to investigate the frequency of undisclosed changes in the outcomes
of randomized controlled trials (RCTs) between trial registration and publication. METHODS …
of randomized controlled trials (RCTs) between trial registration and publication. METHODS …