Precursor messenger RNA (pre-mRNA) splicing is a fundamental step in eukaryotic gene
expression that systematically removes non-coding regions (introns) and ligates coding …

Splicing is the global cellular process whereby intervening sequences (introns) in precursor
messenger RNA (pre‐mRNA) are removed and expressed regions (exons) are ligated …

Alternative splicing generates a myriad of RNA products and protein isoforms of different
functions from a single gene. Dysregulated alternative splicing has emerged as a new …

Splicing of precursor messenger RNA (pre‐mRNA) removes the intervening sequences
(introns) and joins the expressed regions (exons) in the nucleus, before an intron‐containing …

Since its discovery in 1977, much has been known about RNA splicing and how it plays a
central role in human development, function, and, notably, disease. Defects in RNA splicing …

Highlights•Alternative splicing is dynamic and supports all stages of neuronal
function.•Studies reveal molecular mechanisms that direct cell-specific exon …

Alternative splicing is a fundamental mechanism of eukaryotic RNA regulation that increases
the transcriptomic and proteomic complexity within an organism. Moreover, alternative …

Alternative splicing is an important regulator of the transcriptome. However, mutations may
cause alteration of splicing patterns, which in turn leads to disease. During the past 10 …

Splicing of pre-messenger RNA is regulated differently in the brain compared with other
tissues. Recognition of aberrations in splicing events that are associated with neurological …

Highlights•Function of alternative splicing in neurons is not restricted to diversification of
protein families.•Alternative splicing targets mRNA populations to additional RNA …