Major depressive disorder (MDD) is a prevalent psychiatric condition with limited therapeutic
options beyond monoaminergic therapies. Although effective in some individuals, many …

Output properties of neurons are greatly shaped by voltage-gated ion channels, whose
biophysical properties and localization within axodendritic compartments serve to …

Major depressive disorder is a critical public health problem with a lifetime prevalence of
nearly 17% in the United States. One potential therapeutic target is the interaction between …

Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels function in the brain to
limit neuronal excitability. Limiting the activity of these channels has been proposed as a …

Major depressive disorder (MDD) remains a substantial public health problem despite the
existence of many available treatments. One issue with existing pharmacological options is …

The hippocampus is an integral brain region for affective disorders. TRIP8b knockout mice
lacking functional HCN channels as well as both HCN1 and HCN2 knockout mice have …

Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels regulate neuronal
excitability and represent a possible therapeutic target for major depressive disorder (MDD) …

Major depressive disorder (MDD) is a chronic and potentially life threatening illness that
carries a staggering global burden. Characterized by depressed mood, MDD is often difficult …

Abstract Serotonin receptor 4 (5-HT4R) plays an important role in regulating mood, anxiety,
and cognition, and drugs that activate this receptor have fast-acting antidepressant (AD)-like …

Abstract Serotonin 2C receptors (5-HT2CRs) are widely distributed throughout the brain and
are strongly implicated in the pathophysiology of anxiety disorders such as post-traumatic …