Cerebral hemorrhage: pathophysiology, treatment, and future directions

J Magid-Bernstein, R Girard, S Polster… - Circulation …, 2022 - Am Heart Assoc
Intracerebral hemorrhage (ICH) is a devastating form of stroke with high morbidity and
mortality. This review article focuses on the epidemiology, cause, mechanisms of injury …

[HTML][HTML] Pathophysiological mechanisms and potential therapeutic targets in intracerebral hemorrhage

Z Shao, S Tu, A Shao - Frontiers in pharmacology, 2019 - frontiersin.org
Intracerebral hemorrhage (ICH) is a subtype of hemorrhagic stroke with high mortality and
morbidity. The resulting hematoma within brain parenchyma induces a series of adverse …

Inflammation in intracerebral hemorrhage: from mechanisms to clinical translation

Y Zhou, Y Wang, J Wang, RA Stetler, QW Yang - Progress in neurobiology, 2014 - Elsevier
Intracerebral hemorrhage (ICH) accounts for 10–15% of all strokes and is associated with
high mortality and morbidity. Currently, no effective medical treatment is available to improve …

Intracerebral hemorrhage

L Elijovich, PV Patel, JC Hemphill - Seminars in neurology, 2008 - thieme-connect.com
Intracerebral hemorrhage (ICH) accounts for 10 to 15% of all strokes, but results in a
disproportionately high morbidity and mortality. Although chronic hypertension accounts for …

Emerging experimental therapies for intracerebral hemorrhage: targeting mechanisms of secondary brain injury

PK Belur, JJ Chang, S He, BA Emanuel, WJ Mack - Neurosurgical focus, 2013 - thejns.org
Intracerebral hemorrhage (ICH) is associated with a higher degree of morbidity and mortality
than other stroke subtypes. Despite this burden, currently approved treatments have …

Intracerebral haemorrhage

L Puy, AR Parry-Jones, EC Sandset… - Nature Reviews …, 2023 - nature.com
Intracerebral haemorrhage (ICH) is a dramatic condition caused by the rupture of a cerebral
vessel and the entry of blood into the brain parenchyma. ICH is a major contributor to stroke …

[HTML][HTML] Thrombin and hemin as central factors in the mechanisms of intracerebral hemorrhage–induced secondary brain injury and as potential targets for …

R Babu, JH Bagley, C Di, AH Friedman… - Neurosurgical focus, 2012 - thejns.org
Intracerebral hemorrhage (ICH) is a subtype of stoke that may cause significant morbidity
and mortality. Brain injury due to ICH initially occurs within the first few hours as a result of …

[HTML][HTML] Secondary hematoma expansion and perihemorrhagic edema after intracerebral hemorrhage: from bench work to practical aspects

K Lim-Hing, F Rincon - Frontiers in Neurology, 2017 - frontiersin.org
Intracerebral hemorrhages (ICH) represent about 10–15% of all strokes per year in the
United States alone. Key variables influencing the long-term outcome after ICH are …

New era for management of primary hypertensive intracerebral hemorrhage

CE Hall, JC Grotta - Current neurology and neuroscience reports, 2005 - Springer
This discussion focuses on recent reports relevant to improved understanding and future
directions in the management of intracerebral hemorrhage (ICH). Prevention is possible with …

[HTML][HTML] Vascular disruption and blood–brain barrier dysfunction in intracerebral hemorrhage

RF Keep, N Zhou, J Xiang, AV Andjelkovic… - Fluids and Barriers of …, 2014 - Springer
This article reviews current knowledge of the mechanisms underlying the initial hemorrhage
and secondary blood–brain barrier (BBB) dysfunction in primary spontaneous intracerebral …