[HTML][HTML] Non-invasive imaging reveals conditions that impact distribution and persistence of cells after in vivo administration
L Scarfe, A Taylor, J Sharkey, R Harwood… - Stem cell research & …, 2018 - Springer
Background Cell-based regenerative medicine therapies are now frequently tested in
clinical trials. In many conditions, cell therapies are administered systemically, but there is …
clinical trials. In many conditions, cell therapies are administered systemically, but there is …
[HTML][HTML] Preclinical imaging methods for assessing the safety and efficacy of regenerative medicine therapies
L Scarfe, N Brillant, JD Kumar, N Ali… - NPJ Regenerative …, 2017 - nature.com
Regenerative medicine therapies hold enormous potential for a variety of currently incurable
conditions with high unmet clinical need. Most progress in this field to date has been …
conditions with high unmet clinical need. Most progress in this field to date has been …
Concise review: quantitative detection and modeling the in vivo kinetics of therapeutic mesenchymal stem/stromal cells
Mesenchymal stem/stromal cells (MSCs) present a promising tool in cell-based therapy for
treatment of various diseases. Currently, optimization of treatment protocols in clinical …
treatment of various diseases. Currently, optimization of treatment protocols in clinical …
In Vivo Tracking of Systemically Administered Allogeneic Bone Marrow Mesenchymal Stem Cells in Normal Rats through Bioluminescence Imaging
J Cao, S Hou, H Ding, Z Liu, M Song, X Qin… - Stem cells …, 2016 - Wiley Online Library
Recently, mesenchymal stem cells (MSCs) are increasingly used as a panacea for multiple
types of disease short of effective treatment. Dozens of clinical trials published demonstrated …
types of disease short of effective treatment. Dozens of clinical trials published demonstrated …
[HTML][HTML] Imaging technologies for monitoring the safety, efficacy and mechanisms of action of cell-based regenerative medicine therapies in models of kidney disease
J Sharkey, L Scarfe, I Santeramo… - European Journal of …, 2016 - Elsevier
The incidence of end stage kidney disease is rising annually and it is now a global public
health problem. Current treatment options are dialysis or renal transplantation, which apart …
health problem. Current treatment options are dialysis or renal transplantation, which apart …
Biodistribution of mesenchymal stem/stromal cells in a preclinical setting
L Sensebé, S Fleury-Cappellesso - Stem cells international, 2013 - Wiley Online Library
Due to their multi/pluripotency and immunosuppressive properties, mesenchymal
stem/stromal cells (MSCs) are important tools for treatment of immune disorders and tissue …
stem/stromal cells (MSCs) are important tools for treatment of immune disorders and tissue …
Seeing stem cells at work in vivo
AK Srivastava, JWM Bulte - Stem cell reviews and reports, 2014 - Springer
Stem cell based-therapies are novel therapeutic strategies that hold key for developing new
treatments for diseases conditions with very few or no cures. Although there has been an …
treatments for diseases conditions with very few or no cures. Although there has been an …
[HTML][HTML] Options for imaging cellular therapeutics in vivo: a multi-stakeholder perspective
Cell-based therapies have been making great advances toward clinical reality. Despite the
increase in trial activity, few therapies have successfully navigated late-phase clinical trials …
increase in trial activity, few therapies have successfully navigated late-phase clinical trials …
[HTML][HTML] Mesenchymal stem/stromal cell-based therapy: mechanism, systemic safety and biodistribution for precision clinical applications
WZ Zhuang, YH Lin, LJ Su, MS Wu, HY Jeng… - Journal of biomedical …, 2021 - Springer
Mesenchymal stem/stromal cells (MSCs) are a promising resource for cell-based therapy
because of their high immunomodulation ability, tropism towards inflamed and injured …
because of their high immunomodulation ability, tropism towards inflamed and injured …
[HTML][HTML] Intramuscular administration potentiates extended dwell time of mesenchymal stromal cells compared to other routes
LR Braid, CA Wood, DM Wiese, BN Ford - Cytotherapy, 2018 - Elsevier
Abstract Background Mesenchymal stromal cells (MSCs) offer great potential for diverse
clinical applications. However, conventional systemic infusion of MSCs limits their …
clinical applications. However, conventional systemic infusion of MSCs limits their …