Fluoxetine normalizes the effects of prenatal maternal stress on depression-and anxiety-like behaviors in mouse dams and male offspring

AA Salari, L Fatehi-Gharehlar, N Motayagheni… - Behavioural brain …, 2016 - Elsevier
Maternal depression during pregnancy and the postpartum period (lactation) is a common
debilitating condition affecting mother-fetus/-infant interactions, which can be a risk factor for …

Perinatal fluoxetine dose-dependently affects prenatal stress-induced neurobehavioural abnormalities, HPA-axis functioning and underlying brain alterations in rat …

M Amani, DJ Houwing, JR Homberg, AA Salari - Reproductive Toxicology, 2021 - Elsevier
Both untreated and SSRI antidepressant treated maternal depression during the perinatal
period can pose both short-and long-term health risks to the offspring. Therefore, it is …

Fluoxetine during development reverses the effects of prenatal stress on depressive-like behavior and hippocampal neurogenesis in adolescence

I Rayen, DL van den Hove, J Prickaerts… - PloS one, 2011 - journals.plos.org
Depression during pregnancy and the postpartum period is a growing health problem, which
affects up to 20% of women. Currently, selective serotonin reuptake inhibitor (SSRIs) …

Developmental fluoxetine exposure differentially alters central and peripheral measures of the HPA system in adolescent male and female offspring

JL Pawluski, I Rayen, NA Niessen, S Kristensen… - Neuroscience, 2012 - Elsevier
A significant number of women suffer from depression during pregnancy and the postpartum
period. Selective serotonin reuptake inhibitors (SSRIs) are commonly used to treat maternal …

Behavioural outcomes of adult female offspring following maternal stress and perinatal fluoxetine exposure

V Kiryanova, SJ Meunier, RH Dyck - Behavioural brain research, 2017 - Elsevier
Depression, anxiety, and stress are common in pregnant women. One of the primary
pharmacological treatments for anxiety and depression is the antidepressant fluoxetine (Flx) …

Effects of maternal stress and perinatal fluoxetine exposure on behavioral outcomes of adult male offspring

V Kiryanova, SJ Meunier, HA Vecchiarelli, MN Hill… - Neuroscience, 2016 - Elsevier
Women of child-bearing age are the population group at highest risk for depression. In
pregnant women, fluoxetine (Flx) is the most widely prescribed selective serotonin reuptake …

Gestational stress and fluoxetine treatment differentially affect plasticity, methylation and serotonin levels in the PFC and hippocampus of rat dams

M Gemmel, I Rayen, E Van Donkelaar, T Loftus… - Neuroscience, 2016 - Elsevier
Women are more likely to develop depression during childbearing years with up to 20% of
women suffering from depression during pregnancy and in the postpartum period. Increased …

Perinatal fluoxetine increases hippocampal neurogenesis and reverses the lasting effects of pre-gestational stress on serum corticosterone, but not on maternal …

M Gemmel, D Harmeyer, E Bögi, M Fillet, LA Hill… - Behavioural brain …, 2018 - Elsevier
There is increasing evidence that mental health concerns, stress-related mental illnesses,
and parental stress prior to conception have long-term effects on offspring outcomes …

Chronic fluoxetine treatment and maternal adversity differentially alter neurobehavioral outcomes in the rat dam

JL Pawluski, TD Charlier, M Fillet, V Houbart… - Behavioural brain …, 2012 - Elsevier
The incidence of stress and stress-related disorders with the transition to motherhood, such
as postpartum depression, is estimated to be 20%. Selective serotonin reuptake inhibitor …

Prenatal SSRI alters the hormonal and behavioral responses to stress in female mice: Possible role for glucocorticoid resistance

R Avitsur, R Grinshpahet, N Goren, I Weinstein… - Hormones and …, 2016 - Elsevier
Life time prevalence of major depression disorder (MDD) is higher in women compared to
men especially during the period surrounding childbirth. Women suffering from MDD during …