Toll-like receptors (TLRs) sense pathogen-associated molecular patterns to activate the
production of inflammatory mediators. TLR4 recognizes lipopolysaccharide (LPS) and drives …

Cytokines and chemokines are produced and secreted by a broad range of immune cells
including macrophages. Remarkably, little is known about how these inflammatory …

Background: In 1883, Ilya Mechnikov discovered phagocytes and established the concept of
phagocytosis by macrophages. In 1908, he was awarded the Nobel Prize in …

A favorable outcome following acute bacterial infection depends on the ability of phagocytic
cells to be recruited and properly activated within injured tissues. Calcium (Ca 2+) is a …

TRPM2 (transient receptor potential melastatin 2) is the unique fusion of a Ca 2+-permeable
pore with an enzymatic domain that binds the NAD+-metabolite ADP-ribose (ADPR) …

The generation of reactive oxygen species (ROS) is inherent to immune responses. ROS are
crucially involved in host defense against pathogens by promoting bacterial killing, but also …

The enzyme-coupled transient receptor potential channel subfamily M member 7, TRPM7,
has been associated with immunity and immune cell signalling. Here, we review the role of …

TRPMLs (or mucolipins) constitute a family of endosomal cation channels with homology to
the transient receptor potential superfamily. In mammals, the TRPML family includes three …

Macrophages exhibit a phenotypic plasticity that enables them to orchestrate specific
immune responses to distinct threats. The microbial product lipopolysaccharide (LPS) and …

Transient receptor potential melastatin 2 (TRPM2) is a Ca 2+-permeable nonselective cation
channel that is stimulated by oxidative stress and specifically activated by intracellular ADP …