Investigation of the different adrenoceptor targets of nebivolol enantiomers in rat thoracic aorta

T Tran Quang, B Rozec, L Audigane… - British journal of …, 2009 - Wiley Online Library
Background and purpose: Nebivolol is a highly selective β1‐adrenoceptor antagonist with
β3‐adrenoceptor agonist properties and is a racemate mixture of D‐and L‐enantiomers …

Mixed β3‐adrenoceptor agonist and α1‐adrenoceptor antagonist properties of nebivolol in rat thoracic aorta

B Rozec, TT Quang, J Noireaud… - British journal of …, 2006 - Wiley Online Library
Nebivolol, a selective β‐adrenoceptor (β1‐AR) antagonist, induces vasodilatation by an
endothelium‐and NO‐cGMP‐dependent pathway. However, the mechanisms involved in …

Involvement of the β3 adrenoceptor in nebivolol-induced vasorelaxation in the rat aorta

AA de Groot, MJ Mathy, PA van Zwieten… - Journal of …, 2003 - journals.lww.com
Nebivolol is a highly selective β 1 adrenoceptor blocker with additional vasodilating
properties. Although it has been shown that the nebivolol-induced vasorelaxation is nitric …

Nebivolol: endothelium-mediated vasodilating effect

JM Ritter - Journal of cardiovascular pharmacology, 2001 - journals.lww.com
Nebivolol, a racemic mixture of (S, R, R, R) and (R, S, S, S) enantiomers, is the most β 1-
selective adrenoceptor antagonist currently available for clinical use. However, its …

Lack of evidence that nebivolol is a β3-adrenoceptor agonist

EP Frazier, MB Michel-Reher, P van Loenen… - European journal of …, 2011 - Elsevier
Nebivolol is a selective β1-adrenoceptor antagonist which, in addition, displays endothelium-
dependent vasodilating properties in humans and other species. β3-Adrenoceptors have …

Pharmacological Mechanisms of Clinically Favorable Properties of a Selective β1‐Adrenoceptor Antagonist, Nebivolol

A Kuroedov, F Cosentino… - Cardiovascular drug …, 2004 - Wiley Online Library
Nebivolol is a racemic mixture of d‐and 1‐enantiomers. The drug is characterized by β1‐
adrenoceptor selectivity and long‐acting β1‐blockade exerted predominantly by d …

Nebivolol: a selective β1-adrenergic receptor antagonist that relaxes vascular smooth muscle by nitric oxide-and cyclic GMP-dependent mechanisms

LJ Ignarro, RE Byrns, K Trinh, M Sisodia, GM Buga - Nitric Oxide, 2002 - Elsevier
Nebivolol is a highly selective β1-adrenergic receptor antagonist that also possesses
vasodilator properties that are attributed largely to nitric oxide (NO). The objective of the …

β1-adrenoceptor selectivity of nebivolol and bisoprolol. A comparison of [3H] CGP 12.177 and [125I] iodocyanopindolol binding studies

A Bundkirchen, K Brixius, B Bölck, Q Nguyen… - European journal of …, 2003 - Elsevier
There is an ongoing discussion on whether or not high β1-adrenoceptor selectivity of β-
adrenoceptor antagonists may be favorable in the treatment of patients with heart failure …

Different pharmacological properties of two enantiomers in a unique β‐blocker, nebivolol

LJ Ignarro - Cardiovascular therapeutics, 2008 - Wiley Online Library
Nebivolol is a racemic combination of d‐nebivolol (+ SRRR nebivolol) and l‐nebivolol (–
RSSS nebivolol) that differs chemically from other β‐blockers, with an absolutely …

[PDF][PDF] Nebivolol induces endothelium-dependent relaxations of canine coronary arteries

YS Gao, T Nagao, RA Bond, WJ Janssens… - J cardiovasc …, 1991 - academia.edu
Nebivolol is a new ß,-antagonist that acutely reduces arterial blood pressure without
depressing cardiac function. The present study was designed to determine the effect of …